V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 464-477) antibody

Details for Product No. ABIN568738
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Antigen
Epitope
AA 464-477
(121), (73), (67), (60), (58), (50), (34), (32), (29), (22), (20), (17), (16), (15), (13), (11), (11), (9), (8), (7), (7), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(928), (506), (470), (116), (104), (83), (65), (24), (14), (4), (3), (1), (1), (1), (1)
Host
Rabbit
(788), (149), (11), (5), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(31), (25), (24), (19), (14), (13), (10), (10), (10), (10), (10), (10), (10), (10), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(768), (408), (337), (160), (156), (104), (100), (75), (54), (52), (41), (36), (12), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.2 mL
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Catalog No. ABIN568738
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Immunogen Synthetic peptide corresponding to amino acid residues 464-477 of human AKT1
Specificity This peptide sequence is identical in human, mouse, chicken and frog. This peptide sequence is identical in human, mouse, chicken and frog. Species Reactivity: Tested: Human. Expected from sequence similarity: Chicken, Frog, Mouse.
Purification Protein G Chromatography
Alternative Name AKT1 / PKB
Background AKT, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of AKT/PKB is to mediate cell survival. AKT/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and AKT/PKB kinase activity. AKT/PKB phosphorylation is critical for it activity. The major phosphorylation sites required for AKT activation has been identified as threoinine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.
Alternate names: Akt-1, C-AKT, Protein kinase B, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase
Gene ID 207
NCBI Accession NP_001014431
UniProt P31749
Research Area Signaling, Protein Modifications, Kinases/Phosphatases
Restrictions For Research Use only
Format Liquid
Buffer 200 µl PBS containing 0.02% sodium azide and 0.1 mg/ml BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Franke, Kaplan, Cantley: "PI3K: downstream AKTion blocks apoptosis." in: Cell, Vol. 88, Issue 4, pp. 435-7, 1997 (PubMed).

Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

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