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Details for Product No. ABIN568739

Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) (AA 100-200) antibody

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Antigen
Synonyms AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, 2310005E10Rik, Akr1b16, AKR, AKR1B10
Epitope
»Alternatives AA 100-200
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN568739
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Amino acids 100-200 of human AKR1B10
Specificity This antibody reacts to Aldo-keto reductase family 1 member B10 (AKR1B10) Species Reactivity: Tested: Human, Mouse, Rat. Expected from sequence similarity: Chimpanzee.
Purification Protein G Chromatography
Alternative Name AKR1B10
Background ARK1B10, a 316A.A protein, catalyzes efficient reduction of aliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
Alternate names: AKR1B11, ARL-1, Aldo-keto reductase family 1 member B10, Aldose reductase-like, Aldose reductase-related protein, Small intestine reductase
Gene ID 57016
NCBI Accession NP_064695.3
UniProt O60218
Research Area Cancer, Metabolism
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Scuric, Stain, Anderson et al.: "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 27, Issue 4, pp. 943-50, 1998 (PubMed).

Cao, Fan, Chung: "Identification and characterization of a novel human aldose reductase-like gene." in: The Journal of biological chemistry, Vol. 273, Issue 19, pp. 11429-35, 1998 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Crosas, Hyndman, Gallego et al.: "Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism." in: The Biochemical journal, Vol. 373, Issue Pt 3, pp. 973-9, 2003 (PubMed).

Alternatives for antigen "Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10)", type "Antibodies"
Hosts (32), (12), (6)
Reactivities (48), (17), (16), (1), (1)
Applications (35), (23), (19), (10), (10), (8), (6), (4), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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