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Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10) (AA 100-200) antibody

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AA 100-200
(13), (13), (11), (10), (7), (7), (6), (4), (3), (3), (2), (2), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(78), (17), (15), (1), (1)
(45), (17), (16)
(3), (3), (3), (3), (2), (2), (1)
Western Blotting (WB)
(69), (42), (15), (12), (12), (4), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Amino acids 100-200 of human AKR1B10
Specificity This antibody reacts to Aldo-keto reductase family 1 member B10 (AKR1B10) Species Reactivity: Tested: Human, Mouse, Rat. Expected from sequence similarity: Chimpanzee.
Purification Protein G Chromatography
Alternative Name AKR1B10 (AKR1B10 Antibody Abstract)
Background ARK1B10, a 316A.A protein, catalyzes efficient reduction of aliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
Alternate names: AKR1B11, ARL-1, Aldo-keto reductase family 1 member B10, Aldose reductase-like, Aldose reductase-related protein, Small intestine reductase
Gene ID 57016
NCBI Accession NP_064695
UniProt O60218
Research Area Cancer, Metabolism
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Crosas, Hyndman, Gallego et al.: "Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism." in: The Biochemical journal, Vol. 373, Issue Pt 3, pp. 973-9, 2003 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Cao, Fan, Chung: "Identification and characterization of a novel human aldose reductase-like gene." in: The Journal of biological chemistry, Vol. 273, Issue 19, pp. 11429-35, 1998 (PubMed).

Scuric, Stain, Anderson et al.: "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 27, Issue 4, pp. 943-50, 1998 (PubMed).

Catalog No. ABIN568739

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