ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) (AA 25-75) antibody

Details for Product No. ABIN568750
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Antigen
Epitope
AA 25-75
(14), (14), (12), (12), (10), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine)
(130), (72), (57), (33), (14), (10), (6), (2), (1)
Host
Rabbit
(123), (9), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(97), (38), (30), (25), (21), (11), (9), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN568750
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Immunogen Amino acids 25-75 of human APG16L .Remarks: 100% homologous in human, chimpanzee and monkey 94% homologous in dog and mouse 77% homologous in chicken
Specificity Different species have multiple isoforms of APG16L. Human APG16L has at least six isoforms: CRA_a at 607 amino acids, CRA_b at 588 amino acids, CRA_c at 309 amino acids, CRA_d at 374 amino acids, CRA_e at 284 amino acids and CRA_f at 463 amino acids. Multiple isoforms of APG16L can also be detected in mouse skeletal muscle lysate using AP21560PU-N. The approximately 40 kD band seen in skeletal muscle lysate is also seen in
Purification Protein G Chromatography
Alternative Name APG16L / ATG16L1
Background Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The process is found in eukaryotes, including yeast, and involves several genes and two novel ubiquitin-like conjugation systems. The APG12 system is one of the ubiquitin-like protein conjugation systems essential for autophagy. Covalent attachment of APG12–APG5 is essential for autophagy. In mammalian cells, the APG12–APG5 conjugate is a protein complex of approximately 800 kDa and includes an additional novel protein. This novel protein was designated APG16L (APG16-like, also referred to as ATG16L) as it's N-terminal region contains several features similar to yeast APG16. APG16L protein has several spliced isoforms and is larger than yeast APG16 (17 kD). The protein has a large C-terminal domain containing seven WD repeats. Genetic variations in the protein are associated with susceptibility to inflammatory bowel disease type 10. The human APG16L gene is localized in the chromosomal region 2q37.1.
Alternate names: APG16-like 1, Autophagy-related protein 16-1
Gene ID 55054
NCBI Accession NP_001177195
UniProt Q676U5
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Mizushima, Noda, Yoshimori et al.: "A protein conjugation system essential for autophagy." in: Nature, Vol. 395, Issue 6700, pp. 395-8, 1998 (PubMed).

Yeoh, Barton, Kaestner: "The International Journal of Biochemistry & Cell Biology. Preface." in: The international journal of biochemistry & cell biology, Vol. 43, Issue 2, pp. 172, 2011 (PubMed).

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