ATG5 Autophagy Related 5 Homolog (S. Cerevisiae) (ATG5) antibody

Details for Product No. ABIN568753
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Antigen
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(151), (71), (55), (24), (21), (13), (12), (7), (7), (6), (2), (1), (1), (1), (1)
Host
Rabbit
(109), (31), (12), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(136), (77), (74), (25), (19), (10), (9), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN568753
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Immunogen Amino acid 1-50 of human APG5L .Remarks: 100% homologous in human, mouse, rat, pig and bovine 87% homologous in pufferfish 81% homologous in zebrafish
Specificity This antibody reacts to APG5L. Species Reactivity: Tested: Bovine, Human, Mouse, Pig, Rat. Expected from sequence similarity: Pufferfish, Zebrafish.
Purification Peptide affinity chromatography
Alternative Name APG5L / ATG5
Background ATG5L is a 275 amino acid protein belonging to the ATG5 family and is required for autophagy. It plays an important role in the apoptotic process, within the modified cytoskeleton. It is known to function in autophagy, contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). It conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. Down-regulation of its expression in HeLa cells suppresses cell death and vacuole formation induced by IFN-gamma. It is highly expressed in apoptotic cells.
Alternate names: APG5-like, ASP, Apoptosis-specific protein, Autophagy protein 5
Gene ID 9474
NCBI Accession NP_004840
UniProt Q9H1Y0
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Tanida, Tanida-Miyake, Komatsu et al.: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

Pyo, Jang, Kwon et al.: "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death." in: The Journal of biological chemistry, Vol. 280, Issue 21, pp. 20722-9, 2005 (PubMed).

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