ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) (ATG7) (AA 550-600) antibody

Details for Product No. ABIN568754
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AA 550-600
(22), (11), (7), (7), (7), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(96), (29), (16), (1)
(89), (6), (2)
(2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(84), (49), (24), (22), (10), (10), (6), (6), (6), (5), (4), (4), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN568754
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Immunogen Amino acids 550-600 of human APG7L .Remarks: 100% homologous in human, mouse, rat, opossum, and dog
Specificity This antibody reacts to APG7L.
Purification Protein A chromatography
Alternative Name APG7L / ATG7
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. A member of the autophagy family of proteins is APG7L which was identified in yeast as a ubiquitin-E1-like enzyme, this function is conserved in the mammalian homolog. In mammalian cells, APG7L is essential for autophagy conjugation systems, autophagosome formation, and starvation-induced bulk degradation of proteins and organelles. The protein thus plays an indispensable role in the initial step of the conjugation system. APG7L interacts with Apg8p/Aut7p and Aut1p/Apg3p in addition to Apg12p. The protein maps to the 3p25.3-p25.2 region of the human chromosome. Ablation of the protein leads to abnormal swellings and dystrophy of purkinje cell axon terminals in the deep cerebellar nuclei (DCN).
Alternate names: APG7-like, Autophagy-related protein 7, Ubiquitin-activating enzyme E1-like protein
Gene ID 10533
NCBI Accession NP_001129503
UniProt O95352
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Komatsu, Wang, Holstein et al.: "Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 36, pp. 14489-94, 2007 (PubMed).

Komatsu, Waguri, Ueno et al.: "Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice." in: The Journal of cell biology, Vol. 169, Issue 3, pp. 425-34, 2005 (PubMed).

Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, 2004 (PubMed).

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