Aurora Kinase A (AURKA) (AA 100-150) antibody

Details for Product No. ABIN568772
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AA 100-150
(43), (33), (26), (14), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(208), (58), (37), (10), (5), (3), (2), (1), (1), (1), (1), (1)
(154), (55), (21), (1)
(12), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(182), (84), (69), (48), (37), (35), (17), (11), (10), (10), (6), (6), (4), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN568772
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Immunogen Amino acids 100-150 of Human AIK1 .Remarks: The amino acid sequence used is 100% homologous in Human and Chimp, 86% in Bovine and Cat and 80% in Dog.
Specificity This antibody reacts to Aurora/IPL1-Related Kinase 1 (AIK1)/Serine/Threonine Species Reactivity: Tested: Human, Mouse, Rat. Expected from sequence similarity: Chimpanzee, Dog, Bovine, Cat.
Purification Protein G Chromatography
Alternative Name Aurora kinase A
Background ARK1, an Aurora/IPL1-like protein kinase, functions in centrosome separation, duplication, and maturation and in bipolar spindle assembly and stability. The protein has been shown to localize to centrosomes in S phase as soon as centrioles have been duplicated, and to be degraded in early G1. ARK1 phosphorylation is induced by okadaic acid treatment in vivo. Activated ARK1 has been shown to phosphorylate the spindle apparatus-associated protein, TPX2, and it is believed to be targeted to the spindle apparatus by this protein. At least three alternative splice forms have been reported, however, the alternative splice sites are located in the 5'-untranslated region and appear to have no effect on protein translation. ARK1 has been identified as an oncogene that is overexpressed in several types of solid tumors and tumor cell lines, including those from breast and colon. Additionally, overexpression of ARK1 has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy, and genomic instability.
Alternate names: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor- amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
Gene ID 6790
NCBI Accession NP_003591
UniProt O14965
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for six months or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zhou, Kuang, Zhong et al.: "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation." in: Nature genetics, Vol. 20, Issue 2, pp. 189-93, 1998 (PubMed).

Shindo, Nakano, Kuroyanagi et al.: "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2." in: Biochemical and biophysical research communications, Vol. 244, Issue 1, pp. 285-92, 1998 (PubMed).

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