anti-Catalase antibody (CAT)

Details for Product anti-CAT Antibody No. ABIN568858
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Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(167), (71), (53), (48), (14), (11), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1)
(186), (31), (20), (8)
This Catalase antibody is un-conjugated
(27), (11), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(166), (142), (62), (52), (27), (23), (20), (20), (20), (13), (9), (5), (4), (4), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Immunogen The catalase enzyme from bovine liver
Specificity This antibody reacts to Catalase.
Purification Protein A chromatography
Alternative Name Catalase (CAT Antibody Abstract)
Background Catalase is a 527 amino acid heme-containing peroxisomal enzyme belonging to the catalase family. It is a common enzyme that occurs in almost all aerobically respiring organisms and activates the decomposition of hydrogen peroxide, thus serving an important role in protecting cells from the toxic effects of hydrogen peroxide. Catalase, a homotetramer, is associated with cofactors like heme group and NADP and is known to have one of the highest turnover rates of all enzymes. Catalase is a natural antioxidant used to study roles of reactive oxygen species in gene expression and apoptosis. Defects in Catalase lead to a dreadful disease acatalasia, also known as acatalasemia, characterized by the absence of catalase activity in red cells and are often associated with ulcerating oral lesions. Catalase is also known to play an important role in ethanol metabolism, inflammation, apoptosis, aging and cancer.
Alternate names: CAT, Peroxisome Marker
Gene ID 847
NCBI Accession NP_001743
UniProt P04040
Research Area Cancer, Organelles, Heat Shock Proteins, Cell/Tissue Markers
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Taylor, Noguchi, Totoki et al.: "Human chromosome 11 DNA sequence and analysis including novel gene identification. ..." in: Nature, Vol. 440, Issue 7083, pp. 497-500, 2006 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Putnam, Arvai, Bourne et al.: "Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism." in: Journal of molecular biology, Vol. 296, Issue 1, pp. 295-309, 2000 (PubMed).

Catalog No. ABIN568858
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