Epstein-Barr Virus Induced 3 (EBI3) (AA 120-170) antibody

Details for Product No. ABIN568957
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Antigen
Epitope
AA 120-170
(13), (6), (6), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey
(64), (60), (22), (12), (12), (12), (1)
Host
Rabbit
(59), (21), (14), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(78), (56), (18), (16), (15), (11), (10), (10), (4), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN568957
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Immunogen A portion of amino acids 120-170 of human EBI3 .Remarks: 100% homologous in human (isoform CRA_a and CRA_b), chimpanzee 94% homologous in monkey
Specificity This antibody reacts to EBI3. Species Reactivity: Tested: Chimpanzee, Human. Expected from sequence similarity: New World monkey.
Purification Protein G chromatography
Alternative Name EBI3 / IL27B
Background EBI3 is a 229 amino acid cytokine belonging to the type I cytokine receptor family (type 3 subfamily) with a signal peptide, 2 potential N-linked glycosylation sites, an LSDWS motif, 2 fibronectin type-III domains. It is usually induced due to infection of B lymphocytes by Epstein-Barr virus and due to expression of an EBV encoded latent membrane protein. EBI3 is a subunit of two heterodimeric cytokines interleukin-27 (IL27) and IL35. It is a secreted glycoprotein associated with calnexin and is a heterodimer with an alpha and a beta subunit. It is also known to interact with SQSTM1 and is responsible for the rapid clonal expansion of naive but not memory CD4 (+) T-cells. It strongly synergizes with IL-12 and trigger IFN-gamma production of naive CD4 (+) T-cells. It mediates its biologic effects through the cytokine receptor WSX-1/TCCR. It triggers signaling in T cells, B cells, and myeloid cells and along with p35 it acts as an important immunomodulator. It is usually expressed in various hemopoietic tissues and cell lines.
Alternate names: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
Gene ID 10148
NCBI Accession NP_005746
UniProt Q14213
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Pflanz, Timans, Cheung et al.: "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells." in: Immunity, Vol. 16, Issue 6, pp. 779-90, 2002 (PubMed).

Pflanz, Hibbert, Mattson et al.: "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 4, pp. 2225-31, 2004 (PubMed).

Collison, Workman, Kuo et al.: "The inhibitory cytokine IL-35 contributes to regulatory T-cell function." in: Nature, Vol. 450, Issue 7169, pp. 566-9, 2007 (PubMed).

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