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Details for Product No. ABIN568982

Exportin 1, CRM1 Homolog (Yeast) (XPO1) (AA 390-408) antibody

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Antigen
Synonyms
Xpo, crm1, exportin-1, CRM1, emb, exp1, AA420417, Crm1, Exp1, CG13387, DCRM1, Dmel\\CG13387, Emb, XPO-1, XPO1, Xpo1, dCRM1, l(2)k16715, 18.m06600, DDBDRAFT_0183812, DDBDRAFT_0234066, DDB_0183812, DDB_ ... show more
Epitope
»Alternatives AA 390-408
Reactivity
»Alternatives Cow (Bovine), Dog (Canine), Human, Monkey
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN568982
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Amino acids 390-408 (ASPLLSGSQHFDVPPRRQL) of human Exportin-1 protein .Remarks: 100% homologous in human, chimp (isoforms 1-7), bovine, chicken and dog 94% homologous in mouse and rat
Specificity This antibody reacts to Exportin-1/XPO1/CRM1. Species Reactivity: Tested: Chimpanzee, Cow, Dog, Human. Expected from sequence similarity: Mouse, Rat.
Purification Protein G chromatography
Alternative Name XPO1 / Exportin-1
Background Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins. It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.
Alternate names: CRM1, Chromosome region maintenance 1 protein homolog, Exp1
Gene ID 7514
NCBI Accession NP_003391.1
UniProt O14980
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Fornerod, Ohno, Yoshida et al.: "CRM1 is an export receptor for leucine-rich nuclear export signals." in: Cell, Vol. 90, Issue 6, pp. 1051-60, 1997 (PubMed).

Julien, Coulombe, Meloche: "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42615-24, 2003 (PubMed).

Petosa, Schoehn, Askjaer et al.: "Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex." in: Molecular cell, Vol. 16, Issue 5, pp. 761-75, 2004 (PubMed).

Alternatives for antigen "Exportin 1, CRM1 Homolog (Yeast) (XPO1)", type "Antibodies"
Hosts (46)
Reactivities (43), (37), (31), (24), (18), (16), (12), (3), (1), (1)
Applications (26), (20), (13), (10), (5), (3), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (6), (3), (2), (1), (1), (1), (1)
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