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Exportin 1, CRM1 Homolog (Yeast) (XPO1) (AA 390-408) antibody

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AA 390-408
(13), (10), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Human, Monkey
(59), (37), (32), (7), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1)
(57), (2)
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(41), (12), (11), (11), (10), (5), (3), (2), (2), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen Amino acids 390-408 (ASPLLSGSQHFDVPPRRQL) of human Exportin-1 protein .Remarks: 100% homologous in human, chimp (isoforms 1-7), bovine, chicken and dog 94% homologous in mouse and rat
Specificity This antibody reacts to Exportin-1/XPO1/CRM1. Species Reactivity: Tested: Chimpanzee, Cow, Dog, Human. Expected from sequence similarity: Mouse, Rat.
Purification Protein G chromatography
Alternative Name XPO1 / Exportin-1 (XPO1 Antibody Abstract)
Background Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins. It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.
Alternate names: CRM1, Chromosome region maintenance 1 protein homolog, Exp1
Gene ID 7514
NCBI Accession NP_003391
UniProt O14980
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Petosa, Schoehn, Askjaer et al.: "Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex." in: Molecular cell, Vol. 16, Issue 5, pp. 761-75, 2004 (PubMed).

Julien, Coulombe, Meloche: "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42615-24, 2003 (PubMed).

Fornerod, Ohno, Yoshida et al.: "CRM1 is an export receptor for leucine-rich nuclear export signals." in: Cell, Vol. 90, Issue 6, pp. 1051-60, 1997 (PubMed).

Catalog No. ABIN568982

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