Forkhead Box P3 (FOXP3) (Exon 2) antibody

Details for Product No. ABIN569013
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Antigen
Epitope
Exon 2
(72), (18), (7), (7), (7), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Chicken, Horse (Equine), Human, Monkey, Pig (Porcine), Rat (Rattus)
(200), (137), (60), (15), (15), (14), (12), (7)
Host
Rabbit
(161), (60), (43), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(19), (16), (15), (9), (7), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(177), (90), (81), (54), (43), (20), (10), (9), (8), (8), (7), (7), (3), (3)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569013
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Immunogen A synthetic peptide corresponding to the exon 2 deletion site .Remarks: 100% homologous in human (isoforms CRA_a, CRA_b), rhesus monkey, bovine, chicken, horse and pig 92% homologous in cat, mouse and rat 78% homologous in dog
Specificity This antibody reacts to FOXP3/Scurfin. Species Reactivity: Tested: Bovine, Chicken, Horse, Human, Pig, Rat, Rhesus Monkey. Expected from sequence similarity: Cat, Dog, Mouse.
Purification Protein G chromatography
Alternative Name FOXP3
Background One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments, using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FOXP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FOXP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FOXP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
Alternate names: Forkhead box protein P3, IPEX, JM2, Scurfin
Gene ID 20371
NCBI Accession NP_001186276
UniProt Q99JB6
Research Area Immunology, Adaptive Immunity, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Brunkow, Jeffery, Hjerrild et al.: "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse." in: Nature genetics, Vol. 27, Issue 1, pp. 68-73, 2001 (PubMed).

Bettelli, Dastrange, Oukka: "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 14, pp. 5138-43, 2005 (PubMed).

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