MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) (MLST8) (AA 150-200) antibody

Details for Product No. ABIN569019
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Antigen
Epitope
AA 150-200
(19), (8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus)
(71), (38), (27), (13), (12), (11), (2), (1), (1), (1)
Host
Rabbit
(67), (12), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(68), (28), (19), (13), (9), (8), (4), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569019
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Immunogen A portion of amino acids 150-200 of human LST8 .Remarks: 100% homologous in human, mouse, rat, dog, bovine, chicken, chimp and rhesus monkey 93% homologous in xenopus
Specificity This antibody reacts to G protein beta subunit-like/GBL/LST8. Species Reactivity: Tested: Bovine, Chicken, Chimpanzee, Dog, Human, Mouse, Rat, Rhesus Monkey. Expected from sequence similarity: Xenopus.
Purification Protein G chromatography
Alternative Name LST8 / GBL
Background LST8, a 36-40KDa intracellular protein, is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin- receptor activation including insulin-stimulated glucose transport and glycogen synthesis. Northern Blot analysis detected a ubiquitous expression of LST8 with highest expression in brain and testis.
Alternate names: G protein beta subunit-like, Gable, Mammalian lethal with SEC13 protein 8, Protein GbetaL, TORC subunit LST8, Target of rapamycin complex subunit LST8, mLST8
Gene ID 64223
NCBI Accession NP_001186102
UniProt Q9BVC4
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Rodgers, Levine, Bernier et al.: "Insulin regulation of a novel WD-40 repeat protein in adipocytes." in: The Journal of endocrinology, Vol. 168, Issue 2, pp. 325-32, 2001 (PubMed).

Kim, Sarbassov, Ali et al.: "GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR." in: Molecular cell, Vol. 11, Issue 4, pp. 895-904, 2003 (PubMed).

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