GABA(A) Receptor-Associated Protein (GABARAP) (AA 15-31) antibody

Details for Product No. ABIN569033
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Antigen
Epitope
AA 15-31
(18), (5), (3), (2), (2), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(71), (24), (21), (13), (13), (1), (1)
Host
Rabbit
(61), (11), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(66), (36), (16), (10), (8), (6), (5), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN569033
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Immunogen Peptide corresponding to amino acids 15-31 [RSEGEKIRKKYPDRVPV] of GABARAP.
Specificity This antibody reacts to GABA Receptor Associated Protein.
Purification Protein G chromatography
Alternative Name GABARAP
Background GABARAP, a 17KDa microtubule-associated polypeptide, is a novel member of a MAP- protein family which participate in intracellular membrane trafficking. It consists of a basic A.A rich N-terminus, GABA (A) receptor interaction domain and a putative tubulin-binding motif. Localized in the intracellular membranes, GABARAP binds to gamma-2 subunit of GABA (A) receptors and plays a vital role GABA (A) receptor clustering and trafficking to the plasma membrane in neurons. It interacts with various proteins like Gephyrin, tubulin, NSF and transferin receptor and mediates efficient neuronal communication. Role of GABARAP has been implicated as a tumor suppressor in breast cancer.
Alternate names: FLC3B, GABA Receptor Associated Protein, GABA(A) receptor-associated protein, Gamma- aminobutyric acid receptor-associated protein
Gene ID 11337
NCBI Accession NP_009209
UniProt O95166
Research Area Proteolysis / Ubiquitin
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Wang, Bedford, Brandon et al.: "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton." in: Nature, Vol. 397, Issue 6714, pp. 69-72, 1999 (PubMed).

Wang, Olsen: "Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction." in: Journal of neurochemistry, Vol. 75, Issue 2, pp. 644-55, 2000 (PubMed).

Chen, Wang, Vicini et al.: "The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11557-62, 2000 (PubMed).

Bavro, Sola, Bracher et al.: "Crystal structure of the GABA(A)-receptor-associated protein, GABARAP." in: EMBO reports, Vol. 3, Issue 2, pp. 183-9, 2002 (PubMed).

Coyle, Nikolov: "GABARAP: lessons for synaptogenesis." in: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, Vol. 9, Issue 3, pp. 205-16, 2004 (PubMed).

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