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Histone Deacetylase 11 (HDAC11) antibody

Details for Product No. ABIN569056
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Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(64), (29), (18), (12), (12), (1), (1), (1)
Host
Rabbit
(62), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(62), (39), (18), (10), (9), (7), (3), (3), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
Catalog No. ABIN569056
456.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide (AHQGNGHERDFMDDKRVYI) of human HDAC-11. .Remarks: 100% homologous in multiple HDAC11 isoforms
Specificity This antibody reacts to HDAC-11.
Purification Protein G chromatography
Alternative Name HDAC11
Background Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C- terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). Recently, a new member of this family, HDAC-11, has been cloned by Gao et al (4). HDAC-11 transcripts were limited to kidney, heart, brain, skeletal muscle, and testis. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Alternate names: HD11, Histone deacetylase 11
Gene ID 79885
NCBI Accession NP_079103.2
UniProt Q96DB2
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).

Meinke, Liberator: "Histone deacetylase: a target for antiproliferative and antiprotozoal agents." in: Current medicinal chemistry, Vol. 8, Issue 2, pp. 211-35, 2001 (PubMed).

Nakayama, Takami: "Participation of histones and histone-modifying enzymes in cell functions through alterations in chromatin structure." in: Journal of biochemistry, Vol. 129, Issue 4, pp. 491-9, 2001 (PubMed).

Gao, Cueto, Asselbergs et al.: "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family." in: The Journal of biological chemistry, Vol. 277, Issue 28, pp. 25748-55, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN569056
456.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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