Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 84-98) antibody

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Antigen
Epitope
AA 84-98
(29), (15), (8), (7), (6), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(113), (80), (46), (8), (5), (1)
Host
Rabbit
(136), (31), (23), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(22), (12), (7), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(120), (91), (32), (30), (21), (10), (9), (8), (8), (3), (3), (2), (2), (2), (1)
Pubmed 6 references available
Quantity 0.1 mg
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Immunogen A synthetic peptide (SPLYSYTTDGNDTVT) of human HAVCR1/TIM-1 protein. This sequence corresponds to amino acids (aa) 248-262 of NP_036338 and aa 84-98 of EAW61615.1. Isoforms of HAVCR1/TIM-1 have been described. For example, NP_036338 is 364 aa and EAW61615.1 is 194 aa. EAW61615.1 is referred to as isoform CRA_a. .Remarks: 100% homologous in human 93% homologous in vervet/green monkey 80% homologous in chimp
Specificity This antibody reacts to Hepatitis A virus cellular receptor 1 (HAVCR1)/TIM-1. Species Reactivity: Tested: Human, Mouse. Expected from sequence similarity: New World monkey.
Purification Protein G chromatography
Alternative Name TIMD1 / HAVCR1 (HAVCR1 Antibody Abstract)
Background HAVCR1/TIM-1, a Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.
Alternate names: HAVCR-1, Hepatitis A virus cellular receptor 1, T cell immunoglobulin and mucin domain- containing protein 1, T cell membrane protein 1, TIM-1, TIM1, TIMD-1
Gene ID 26762
NCBI Accession NP_001092884
UniProt Q96D42
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Umetsu, Umetsu, Freeman et al.: "TIM gene family and their role in atopic diseases." in: Current topics in microbiology and immunology, Vol. 321, pp. 201-15, 2008 (PubMed).

Vilà, Kaplan, Feigelstock et al.: "Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma." in: Kidney international, Vol. 65, Issue 5, pp. 1761-73, 2004 (PubMed).

McIntire, Umetsu, DeKruyff: "TIM-1, a novel allergy and asthma susceptibility gene." in: Springer seminars in immunopathology, Vol. 25, Issue 3-4, pp. 335-48, 2004 (PubMed).

Chae, Song, Heo et al.: "Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma." in: Human immunology, Vol. 64, Issue 12, pp. 1177-82, 2003 (PubMed).

McIntire, Umetsu, Akbari et al.: "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family." in: Nature immunology, Vol. 2, Issue 12, pp. 1109-16, 2001 (PubMed).

Feigelstock, Thompson, Mattoo et al.: "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor." in: Journal of virology, Vol. 72, Issue 8, pp. 6621-8, 1998 (PubMed).

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Catalog No. ABIN569063
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