High Mobility Group Box 3 (HMGB3) (AA 1-50), (N-Term) antibody

Details for Product No. ABIN569079
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AA 1-50, N-Term
(17), (17), (15), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Cow (Bovine), Horse (Equine), Human, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus)
(59), (11), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1)
(42), (16), (4), (1)
(3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(60), (26), (8), (5), (4), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN569079
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Immunogen A portion of amino acids 1-50 of human HMGB3 .Remarks: 100% homologous in human, mouse, rat, opossum, horse and cow 93% homologous in chicken and Xenopus 81% homologous in zebrafish
Specificity This antibody reacts to HMGB3. Species Reactivity: Tested: Cow, Horse, Human, Mouse, Opossum, Rat. Expected from sequence similarity: Chicken, Xenopus, Zebrafish.
Purification Protein A chromatography
Alternative Name HMGB3
Background HMGB3, also known as High mobility group protein B3, is a DNA associated protein that binds preferentially single-stranded DNA and unwinds double stranded DNA. This transcription factor belongs to the HMGB family and high mobility group (HMG) protein superfamily and contains two HMG box DNA-binding domains. Like other members of the family, HMGB3 plays a fundamental role in DNA replication, nucleosome assembly and transcription. Other functions include regulation of balance between hematopoietic stem cell self-renewal and differentiation and may also be required during embryonic development. HMGB3 is predominantly expressed in placenta.
Alternate names: HMG-2a, HMG-4, HMG2A, HMG4, HMGB-3, High mobility group protein 2a, High mobility group protein 4, High mobility group protein B3
Gene ID 3149
NCBI Accession NP_005333
UniProt O15347
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Nemeth, Kirby, Bodine: "Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 37, pp. 13783-8, 2006 (PubMed).

Nemeth, Curtis, Kirby et al.: "Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation." in: Blood, Vol. 102, Issue 4, pp. 1298-306, 2003 (PubMed).

Vaccari, Beltrame, Ferrari et al.: "Hmg4, a new member of the Hmg1/2 gene family." in: Genomics, Vol. 49, Issue 2, pp. 247-52, 1998 (PubMed).

Wilke, Wiemann, Gaul et al.: "Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region." in: Gene, Vol. 198, Issue 1-2, pp. 269-74, 1997 (PubMed).

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