IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 350-400) antibody

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AA 350-400
(16), (15), (14), (5), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Human, Monkey
(97), (47), (22), (5), (3), (2), (2), (2), (1), (1), (1)
(68), (45)
(8), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(75), (42), (14), (13), (10), (10), (7), (7), (4), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Immunogen Amino acids 350-400 of human IKZF3 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, chimpanzee and rheseus monkey, 88% homologous cow and dog, 83% homologous in horse, platypus, and 77% homologous in rat and mouse.
Specificity This antibody detects ZNFN1A3 (IKZF3, Aiolos). Species Reactivity: Tested: Chimpanzee, Human, Rhesus Monkey Expected from sequence similarity: Cow, Dog, Horse, Mouse, Rat
Purification Antigen affinity chromatography
Alternative Name ZNFN1A3 (IKZF3, Aiolos) (IKZF3 Antibody Abstract)
Background IKZF3 is a hemopoietic zinc finger DNA-binding protein that acts as a central regulator of lymphoid differentiation and is implicated in leukemogenesis. It is a 509 amino acid containing nuclear protein and a member of the IKAROS family of C2H2- type zinc-finger proteins and zinc finger protein, subfamily 1A with six C2H2- type zinc-fingers. IKZF3 may form homodimers or heterodimers and is known to interact with IKZF4 and IKZF5. A well known transcription factor, IKZF3, plays an important role in the regulation of B lymphocyte proliferation and differentiation and participates in chromatin remodeling. IKZF3 plays a role in the control of T cell death by regulating the expression of BCL2 in acute lymphoblastic leukemia. Strong expression of IKZF3 is usually detected in peripheral blood leukocytes, spleen and thymus and low expression in liver, small intestine, and lung.
Alternate names: Ikaros family zinc finger protein 3, Zinc finger protein Aiolos
Gene ID 22806
NCBI Accession NP_036613
UniProt Q9UKT9
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Mullighan, Goorha, Radtke et al.: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." in: Nature, Vol. 446, Issue 7137, pp. 758-64, 2007 (PubMed).

Cortés, Georgopoulos: "Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity." in: The Journal of experimental medicine, Vol. 199, Issue 2, pp. 209-19, 2004 (PubMed).

Schmitt, Tonnelle, Dalloul et al.: "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation." in: Apoptosis : an international journal on programmed cell death, Vol. 7, Issue 3, pp. 277-84, 2002 (PubMed).

Wang, Avitahl, Cariappa et al.: "Aiolos regulates B cell activation and maturation to effector state." in: Immunity, Vol. 9, Issue 4, pp. 543-53, 1998 (PubMed).

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Catalog No. ABIN569110
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