Interleukin 18 Binding Protein (IL18BP) (AA 44-55) antibody

Details for Product No. ABIN569112
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AA 44-55
(12), (11), (9), (5), (4), (3), (2), (1), (1), (1), (1)
(62), (33), (22)
(66), (11), (8)
(11), (6), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(60), (52), (13), (10), (8), (8), (7), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Immunogen Peptide corresponding to amino acids 44-55 [STKDPCPSQPPVC] of the 40 kDa human IL-18BP.
Specificity This antibody reacts to IL-18BP.
Purification Protein G chromatography
Alternative Name IL18BP (IL18BP Antibody Abstract)
Background IL-18BP, a 40KDa glycoprotein, is a member of Ig super family. It consists of a single Ig-like domain and acts as a circulating anti-inflammatory protein. It is a secretory protein which binds to IL-18 with high affinity and prevents its interaction with IL-18R, resulting in inhibition of IL-18 induced IFN-gamma, IL-8 and NF-kB production. Its expression is up- regulated by IFN-gamma, thus providing a negative feed-back mechanism in shutting off IL-18 mediated immune responses. It is constitutively expressed in mononuclear cells and its role has been implicated in treatment of contact hypersensitivity. Northern Blot analysis detected a strong expression in spleen and its pathological implications have been observed in Crohn’s disease.
Alternate names: IL-18BP, Interleukin-18-binding protein, Tadekinig-alfa
Gene ID 10068
NCBI Accession NP_001034748
UniProt O95998
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Plitz, Saint-Mézard, Satho et al.: "IL-18 binding protein protects against contact hypersensitivity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 3, pp. 1164-71, 2003 (PubMed).

Hurgin, Novick, Rubinstein: "The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16957-62, 2002 (PubMed).

Corbaz, ten Hove, Herren et al.: "IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3608-16, 2002 (PubMed).

Novick, Kim, Fantuzzi et al.: "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response." in: Immunity, Vol. 10, Issue 1, pp. 127-36, 1999 (PubMed).

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Catalog No. ABIN569112
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