Interleukin 18 Binding Protein (IL18BP) (AA 44-55) antibody

Details for Product No. ABIN569112
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Antigen
Synonyms IL18BPa, MC54L, Igifbp, IL-18BP, IL18BP
Epitope
AA 44-55
(5), (3), (3), (2)
Reactivity
Human
(36), (29), (16), (12), (12)
Host
Rabbit
(46), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (36), (11), (10), (7), (5), (3), (3), (1), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN569112
Quantity 0.1 mg
Price
423.50 $   Plus shipping costs $45.00
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Availability Discontinued
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Immunogen Peptide corresponding to amino acids 44-55 [STKDPCPSQPPVC] of the 40 kDa human IL-18BP.
Specificity This antibody reacts to IL-18BP.
Purification Protein G chromatography
Alternative Name IL18BP
Background IL-18BP, a 40KDa glycoprotein, is a member of Ig super family. It consists of a single Ig-like domain and acts as a circulating anti-inflammatory protein. It is a secretory protein which binds to IL-18 with high affinity and prevents its interaction with IL-18R, resulting in inhibition of IL-18 induced IFN-gamma, IL-8 and NF-kB production. Its expression is up- regulated by IFN-gamma, thus providing a negative feed-back mechanism in shutting off IL-18 mediated immune responses. It is constitutively expressed in mononuclear cells and its role has been implicated in treatment of contact hypersensitivity. Northern Blot analysis detected a strong expression in spleen and its pathological implications have been observed in Crohn’s disease.
Alternate names: IL-18BP, Interleukin-18-binding protein, Tadekinig-alfa
Gene ID 10068
NCBI Accession NP_001034748.1
UniProt O95998
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Novick, Kim, Fantuzzi et al.: "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response." in: Immunity, Vol. 10, Issue 1, pp. 127-36, 1999 (PubMed).

Corbaz, ten Hove, Herren et al.: "IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3608-16, 2002 (PubMed).

Hurgin, Novick, Rubinstein: "The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16957-62, 2002 (PubMed).

Plitz, Saint-Mézard, Satho et al.: "IL-18 binding protein protects against contact hypersensitivity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 3, pp. 1164-71, 2003 (PubMed).

Hosts (46), (6), (4)
Reactivities (36), (29), (16), (12), (12)
Applications (43), (36), (11), (10), (7), (5), (3), (3), (1), (1), (1), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (3), (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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