Influenza A H1N1 (AA 24-39) antibody

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Antigen
Epitope
AA 24-39
(2), (1)
Reactivity
Influenza A Virus H1N1
(31), (1), (1)
Host
Rabbit
(19), (9), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (2)
Application
Western Blotting (WB)
(18), (14), (12), (8), (8), (3), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN569125
Quantity 0.1 mg
Price
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Immunogen Amino acids 24-39 (DQKLGDAPFLDRLRRD) of human Influenza A H1N1 nonstructural protein .Remarks: 100% homologous in strains H1N1, H3N2, H5N1, H6N1, H6N2 and H9N2 93% homologous in H7N7
Specificity This antibody reacts to Influenza A NS.
Purification Antigen Affinity Chromatography
Background On 6/09/2009, the World Health Organization classified swine flu influenza (H1N1) to be the first influenza pandemic of the 21st century. Elucidating risk factors, illness patterns and transmission characteristics are among the highest priorities in H1N1 epidemiological studies. Influenza A H1N1 NS, also known as Non-structural protein 1 or NS1A or NS1, is a 234 amino acid containing protein belonging to the Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1) which has aves, human and pig as host. This protein belongs to the influenza A viruses NS1 family and is a homodimer located in the nucleus of uninfected, transfected cells, and in the cytoplasm of infected cells. The viral protein NS1 binds to and inhibits two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs which include the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). Thus inhibiting post-transcriptional processing of cellular pre-mRNA and leading to accumulation of unprocessed 3' end pre-mRNAs in nucleus and loss of cellular protein synthesis. This helps the virus to escape interferon synthesis after activation of the IRF3 pathway, and therefore prevents establishment of cellular antiviral state. NS1 is also known to prevent human EIF2AK2/PKR activation, at the very beginning of the infection, when NS1 is mainly present in the cytoplasm and prevent antiviral response.
Alternate names: Seasonal Flu H1N1
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Nakajima, Nobusawa, Nakajima: "Genetic relatedness between A/Swine/Iowa/15/30(H1N1) and human influenza viruses." in: Virology, Vol. 139, Issue 1, pp. 194-8, 1984 (PubMed).

Krug, Yuan, Noah et al.: "Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein." in: Virology, Vol. 309, Issue 2, pp. 181-9, 2003 (PubMed).

Hosts (19), (9), (5)
Reactivities (31), (1), (1)
Applications (18), (14), (12), (8), (8), (3), (1), (1), (1)
Conjugates (6), (3), (2)
Epitopes (2), (1)
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