Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 13-30) antibody

Details for Product No. ABIN569160
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AA 13-30
(24), (8), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(108), (17), (16), (13), (13)
(81), (16), (12)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(90), (34), (26), (23), (10), (9), (7), (6), (5), (5), (4), (3), (2), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN569160
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Immunogen Peptide corresponding to amino acids 13-30 of Livin
Specificity This antibody detects BIRC7 / LIVIN. Species Reactivity: Tested: Human
Purification Protein G purified
Alternative Name BIRC7 / LIVIN
Background Livin is a member of IAP family characterized by the presence of an N-terminal, conserved, single BIR domain and a C-terminal RING-type zinc finger domain. It plays a vital role in caspase regulation, anti-apoptosis and tumorigenesis. Livin interacts with diverse pro- apoptotic factors and inhibits apoptosis triggered by various death stimuli in a caspase- dependent and caspase-independent methods. BIR domain of Livin binds to caspase-9, inhibits its proteolysis and induces a caspase-dependent anti-apoptotic cascade. Alternatively, Livin has also been found to activate MAP kinase and inhibit apoptosis via TAK1/JNK1 signaling cascade. Northern Blot analysis detected an elevated expression in developmental tissues and human melanomas, suggesting a potential cancer target.
Alternate names: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Gene ID 79444
NCBI Accession NP_071444
UniProt Q96CA5
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Yagihashi, Asanuma, Tsuji et al.: "Detection of anti-livin antibody in gastrointestinal cancer patients." in: Clinical chemistry, Vol. 49, Issue 7, pp. 1206-8, 2003 (PubMed).

Sanna, da Silva Correia, Ducrey et al.: "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1754-66, 2002 (PubMed).

Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).

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