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Baculoviral IAP Repeat-Containing 7 (BIRC7) (AA 13-30) antibody

Details for Product No. ABIN569160
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Antigen
Epitope
AA 13-30
(21), (6), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(97), (17), (16), (13), (13)
Host
Rabbit
(74), (13), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(81), (34), (24), (19), (10), (6), (6), (5), (5), (3), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569160
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Immunogen Peptide corresponding to amino acids 13-30 of Livin
Sequence GPQPSHWAAGDGPTQERC
Specificity This antibody detects BIRC7 / LIVIN. Species Reactivity: Tested: Human
Purification Protein G purified
Alternative Name BIRC7 / LIVIN
Background Livin is a member of IAP family characterized by the presence of an N-terminal, conserved, single BIR domain and a C-terminal RING-type zinc finger domain. It plays a vital role in caspase regulation, anti-apoptosis and tumorigenesis. Livin interacts with diverse pro- apoptotic factors and inhibits apoptosis triggered by various death stimuli in a caspase- dependent and caspase-independent methods. BIR domain of Livin binds to caspase-9, inhibits its proteolysis and induces a caspase-dependent anti-apoptotic cascade. Alternatively, Livin has also been found to activate MAP kinase and inhibit apoptosis via TAK1/JNK1 signaling cascade. Northern Blot analysis detected an elevated expression in developmental tissues and human melanomas, suggesting a potential cancer target.
Alternate names: Baculoviral IAP repeat-containing protein 7, KIAP, Kidney inhibitor of apoptosis protein, Livin, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50
Gene ID 79444
NCBI Accession NP_071444.1
UniProt Q96CA5
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kasof, Gomes: "Livin, a novel inhibitor of apoptosis protein family member." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3238-46, 2001 (PubMed).

Sanna, da Silva Correia, Ducrey et al.: "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1754-66, 2002 (PubMed).

Yagihashi, Asanuma, Tsuji et al.: "Detection of anti-livin antibody in gastrointestinal cancer patients." in: Clinical chemistry, Vol. 49, Issue 7, pp. 1206-8, 2003 (PubMed).

Validation Images
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