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Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (AA 1-50), (N-Term) antibody

Details for Product No. ABIN569175
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Antigen
Epitope
AA 1-50, N-Term
(24), (22), (13), (11), (10), (10), (10), (7), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Monkey, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus)
(175), (84), (74), (42), (25), (25), (15), (12), (3), (3), (1), (1), (1)
Host
Rabbit
(153), (19), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (10), (10), (10), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(139), (69), (59), (39), (30), (30), (20), (16), (15), (10), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569175
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Immunogen Amino acids 1-50 of human ATG8 (MAP1LC3A) .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, cow, monkey, rat, opossum and zebrafish, 93% in mouse, 86% in chicken and 80% homologous in chimpanzee and xenopus.
Specificity This antibody detects LC3A. Species Reactivity: Tested: Cow, Human, New World monkey, Opossum, Rat Expected from sequence similarity: Mouse, Chimpanzee, Pufferfish, Xenopus, Chicken
Purification Protein G chromatography
Alternative Name LC3
Background MAP1A and MAP1B are microtubule-associated proteins made up of a heavy chain and multiple light chain components. One such light chain component associated with these proteins is ATG8. ATG8 (MAP1LC3A, APG8), an ~16KDa mammalian homolog of yeast Atg8, is a cytoplasmic protein that plays an essential role in the process and regulation of autophagy. ATG8 is an evolutionarily conserved protein that belongs to LC3 family. ATG8 interacts with various proteins in the cytoplasm including mammalian homologues of Atg4, Atg7, Atg3 and Atg12 and gets modified into LC3-I and LC3-II respectively. Both of these forms are suggested to be involved in the formation and intracellular trafficking of autophagosomes in mammalian cells.
Alternate names: Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, LC3A, MAP1 light chain 3-like protein 1, MAP1A / 1B light chain 3 A, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1LC3A, Microtubule-associated protein 1 light chain 3 alpha, Microtubule-associated proteins 1A/1B light chain 3A
Gene ID 84557
NCBI Accession NP_115903.1
UniProt Q9H492
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kabeya, Mizushima, Ueno et al.: "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing." in: The EMBO journal, Vol. 19, Issue 21, pp. 5720-8, 2000 (PubMed).

Kouno, Mizuguchi, Tanida et al.: "Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24610-7, 2005 (PubMed).

Validation Images
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