Meis Homeobox 1 (MEIS1) (AA 280-330) antibody

Details for Product No. ABIN569183
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AA 280-330
(9), (9), (4), (3), (3), (2), (1), (1), (1), (1)
Dog (Canine), Chicken, Horse (Equine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(51), (23), (17), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1)
(36), (15), (3)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(39), (17), (10), (5), (4), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN569183
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Immunogen Amino acids 280-330 of MEIS1 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, rat, mouse, chicken, horse, dog and Xenopus. Two isoforms have been reported.
Specificity This antibody detects MEIS1. Species Reactivity: Tested: Chicken, Dog, Horse, Human, Mouse, Rat, Xenopus
Purification Antigen affinity chromatography
Alternative Name MEIS1
Background MEIS1, also known as Homeobox protein Meis1, is a nuclear protein belonging to the TALE/MEIS homeobox family with a homeobox DNA-binding domain. It acts as a transcriptional regulator of PAX6 (Paired box protein Pax-6). It is a protein required for hematopoiesis, megakaryocyte lineage development and vascular patterning. Expression is seen at low levels in normal immunohepatopoietic tissues, and in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic- erythroid phenotype. It is also expressed at high levels in the cerebellum.
Alternate names: Homeobox protein Meis1
Gene ID 4211
NCBI Accession NP_002389
UniProt O00470
Research Area Stem Cells, Hematopoietic Progenitors, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Wong, Iwasaki, Somervaille et al.: "Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential." in: Genes & development, Vol. 21, Issue 21, pp. 2762-74, 2007 (PubMed).

Hisa, Spence, Rachel et al.: "Hematopoietic, angiogenic and eye defects in Meis1 mutant animals." in: The EMBO journal, Vol. 23, Issue 2, pp. 450-9, 2004 (PubMed).

Thorsteinsdottir, Kroon, Jerome et al.: "Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia." in: Molecular and cellular biology, Vol. 21, Issue 1, pp. 224-34, 2001 (PubMed).

Steelman, Moskow, Muzynski et al.: "Identification of a conserved family of Meis1-related homeobox genes." in: Genome research, Vol. 7, Issue 2, pp. 142-56, 1997 (PubMed).

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