NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 493-509) antibody

Details for Product No. ABIN569207
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Antigen
Synonyms Nalp10, 6430548I20Rik, Napl10, PAN5, Pynod, CLR11.1, NALP10, NOD8, PYNOD
Epitope
AA 493-509
(12), (1), (1), (1)
Reactivity
Horse (Equine), Human, Rhesus Monkey
(24), (3), (1)
Host
Rabbit
(25), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (14), (9), (5), (5), (2), (1)
Pubmed 2 references available
Catalog no. ABIN569207
Quantity 0.1 mg
Price
456.50 $   Plus shipping costs $45.00
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Immunogen Amino acids 493-509 of human NALP10 protein
Sequence REVQRLLEVKEQEGNDE
Specificity This antibody detects NALP10. Species Reactivity: Tested: Human Expected from sequence similarity: Horse, Rhesus Monkey
Purification Protein A chromatography
Alternative Name NLRP10
Background NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
Alternate names: NACHT LRR and PYD domains-containing protein 10, NALP10, NOD8, Nucleotide-binding oligomerization domain protein 8, PYNOD
Gene ID 338322
NCBI Accession NP_789791.1
UniProt Q86W26
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Wang, Hasegawa, Imamura et al.: "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1." in: International immunology, Vol. 16, Issue 6, pp. 777-86, 2004 (PubMed).

Hosts (25), (3), (1)
Reactivities (24), (3), (1)
Applications (18), (14), (9), (5), (5), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (1), (1), (1)
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