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NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 493-509) antibody

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AA 493-509
(16), (15), (12), (3), (2), (2), (1), (1)
Horse (Equine), Human, Rhesus Monkey
(53), (3), (3)
(51), (2), (1)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(41), (29), (11), (8), (7), (5), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Amino acids 493-509 of human NALP10 protein
Specificity This antibody detects NALP10. Species Reactivity: Tested: Human Expected from sequence similarity: Horse, Rhesus Monkey
Purification Protein A chromatography
Alternative Name NLRP10 (NLRP10 Antibody Abstract)
Background NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
Alternate names: NACHT LRR and PYD domains-containing protein 10, NALP10, NOD8, Nucleotide-binding oligomerization domain protein 8, PYNOD
Gene ID 338322
NCBI Accession NP_789791
UniProt Q86W26
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Wang, Hasegawa, Imamura et al.: "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1." in: International immunology, Vol. 16, Issue 6, pp. 777-86, 2004 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Catalog No. ABIN569207

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