NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 493-509) antibody

Details for Product No. ABIN569207
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Antigen
Epitope
AA 493-509
(10), (7), (6), (1), (1), (1), (1)
Reactivity
Horse (Equine), Human, Rhesus Monkey
(32), (1)
Host
Rabbit
(31), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (17), (9), (5), (5)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569207
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Immunogen Amino acids 493-509 of human NALP10 protein
Sequence REVQRLLEVK EQEGNDE
Specificity This antibody detects NALP10. Species Reactivity: Tested: Human Expected from sequence similarity: Horse, Rhesus Monkey
Purification Protein A chromatography
Alternative Name NLRP10
Background NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
Alternate names: NACHT LRR and PYD domains-containing protein 10, NALP10, NOD8, Nucleotide-binding oligomerization domain protein 8, PYNOD
Gene ID 338322
NCBI Accession NP_789791
UniProt Q86W26
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Wang, Hasegawa, Imamura et al.: "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1." in: International immunology, Vol. 16, Issue 6, pp. 777-86, 2004 (PubMed).

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