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NLR Family, Pyrin Domain Containing 11 (NLRP11) (AA 850-900) antibody

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AA 850-900
(10), (3), (3), (2), (1)
(17), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(16), (12), (6), (5), (4), (4), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mL
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Immunogen Amino acids 850-900 of human NALP11 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, 88% homologous in monkey, and 62% homologous in mouse.
Specificity This antibody detects NALP2. Species Reactivity: Tested: Human Expected from sequence similarity: New World monkey, Mouse
Purification Protein A chromatography
Alternative Name NALP11 (NLRP11 Antibody Abstract)
Background NALP11 is a 1033 amino acid containing cytoplasmic protein belonging to the NLRP family with a DAPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. The DAPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.
Alternate names: LRR and PYD domains-containing protein 11, NACHT, NLRP11, NOD17, Nucleotide-binding oligomerization domain protein 17, PYPAF6, PYRIN-containing APAF1-like protein 6
Gene ID 204801
NCBI Accession NP_659444
UniProt P59045
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Inohara, Nuñez: "NODs: intracellular proteins involved in inflammation and apoptosis." in: Nature reviews. Immunology, Vol. 3, Issue 5, pp. 371-82, 2003 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Catalog No. ABIN569208

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