NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 130-180) antibody

Details for Product No. ABIN569211
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Antigen
Epitope
AA 130-180
(18), (7), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chimpanzee, Human
(51), (28), (11), (1), (1), (1)
Host
Rabbit
(51), (4), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(56), (21), (16), (8), (7), (4), (4), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569211
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Immunogen Amino acids 130-180 of human NALP2 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a and CRA_d) and 94% homologous in chimpanzee.
Specificity This antibody detects NALP2. Species Reactivity: Tested: Human Expected from sequence similarity: Chimpanzee
Purification Antigen affinity chromatography
Alternative Name NALP2
Background NALP2 is a 1062 amino acid containing cytosolic protein, belonging to the NLRP family and is characterized by the presence of an N-terminal pyrin domain (PYD), eight leucine rich repeats and a NACHT domain. This protein is involved in the activation of caspase-1 by Toll- like receptors and may also be involved in protein complexes that activate proinflammatory caspases. The DAPIN domain of NALP2 helps in suppressing TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. NALP2 is known to interact with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. It is widely expressed in most of the tissues with high expression in lung, placenta and thymus, low expression in ovary, intestine and brain and variably in some cancer cell lines.
Alternate names: LRR and PYD domains-containing protein 2, NACHT, NBS1, NLRP2, PAN1, PYPAF2
Gene ID 55655
NCBI Accession NP_001167552
UniProt Q9NX02
Research Area Apoptosis/Necrosis
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Agostini, Martinon, Burns et al.: "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." in: Immunity, Vol. 20, Issue 3, pp. 319-25, 2004 (PubMed).

Bruey, Bruey-Sedano, Newman et al.: "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 51897-907, 2004 (PubMed).

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