NLR Family, Pyrin Domain Containing 3 (NLRP3) (AA 1-50), (N-Term) antibody

Details for Product No. ABIN569214
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Antigen
Epitope
AA 1-50, N-Term
(23), (8), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
(94), (37), (30), (16), (5), (2)
Host
Rabbit
(59), (19), (17), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(64), (40), (21), (20), (14), (7), (7), (6), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN569214
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Immunogen A portion of amino acids 1-50 of Human NALP3 was used as the immunogen .Remarks: The amino acid sequence used as immunogen is 100% homologous in Human and Monkey and 86% homologous in Mouse and Rat.
Isotype IgG
Specificity This antibody detects NALP3. Species Reactivity: Tested: Human, New World Monkey, Mouse, Rat
Purification Protein A Chromatography
Alternative Name NALP3
Background NACHT, LRR and PYD domains-containing protein 3 belongs to the NLRP family and it contains one DAPIN domain, seven LRR (leucine-rich) repeats and one NATCH domain. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling and it plays a role in the regulation of inflammation, the immune response and apoptosis. It is also reported that the NLRP3 inflammasome can be activated by pathogen-associated molecular patterns (PAMPs) or endogenous danger-associated molecular patterns (DAMPs). The activation of the NLRP3 inflammasome results in proteolytic activation and secretion of cytokines of the interleukin-1 (IL-1) family. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome and neonatal-onset multi-system inflammatory disease (NOMID).
Alternate names: C1orf7, CIAS1, LRR and PYD domains-containing protein 3, NACHT, NLRP3, PYPAF1
Gene ID 114548
NCBI Accession NP_004886
UniProt Q96P20
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Agostini, Martinon, Burns et al.: "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." in: Immunity, Vol. 20, Issue 3, pp. 319-25, 2004 (PubMed).

Kummer, Broekhuizen, Everett et al.: "Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 55, Issue 5, pp. 443-52, 2007 (PubMed).

van Bruggen, Köker, Jansen et al.: "Human NLRP3 inflammasome activation is Nox1-4 independent." in: Blood, Vol. 115, Issue 26, pp. 5398-400, 2010 (PubMed).

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