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NLR Family, Pyrin Domain Containing 7 (NLRP7) (AA 106-122) antibody

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AA 106-122
(11), (2), (1), (1), (1)
Human, Monkey
(34), (2), (2)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(20), (13), (11), (9), (7), (3), (3), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to amino acids 106-122 human NALP7
Specificity This antibody detects NLRP7. Species Reactivity: Tested: Human, Rhesus Monkey
Purification Antigen Affinity Chromatography
Alternative Name NLRP7 (NLRP7 Antibody Abstract)
Background NALP7 is a 980 amino acid containing short NALP belonging to the NLRP family with a DAPIN domain, nine LRR (leucine-rich) repeats and a NACHT domain. NALP7 is usually induced by LPS and IL-1B in peripheral blood mononuclear cells. A PYRIN-containing APAF-1-like protein, NALP7 directly interacts with CASP1 and IL-1B and acts as a feedback regulator of CASP1/caspase-1-dependent interleukin-1 beta secretion. It may play a crucial role in cell proliferation. Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain but not detected in skeletal muscle. Defects in NLRP7 are the cause of hydatidiform mole (HYDM), an abnormal human pregnancy with no embryo and cystic degeneration of placental villi.
Alternate names: LRR and PYD domains-containing protein 7, NALP7, NOD12, Nucleotide-binding oligomerization domain protein 12, PYPAF3, PYRIN-containing APAF1-like protein 3
Gene ID 199713
NCBI Accession NP_001120727
UniProt Q8WX94
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Murdoch, Djuric, Mazhar et al.: "Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans." in: Nature genetics, Vol. 38, Issue 3, pp. 300-2, 2006 (PubMed).

Kinoshita, Wang, Hasegawa et al.: "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion." in: The Journal of biological chemistry, Vol. 280, Issue 23, pp. 21720-5, 2005 (PubMed).

Okada, Hirota, Mizutani et al.: "Oncogenic role of NALP7 in testicular seminomas." in: Cancer science, Vol. 95, Issue 12, pp. 949-54, 2004 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Catalog No. ABIN569216

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