You are viewing an incomplete version of our website. Please click to reload the website as full version.

Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 582-600) antibody

Details for Product No. ABIN569245, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

AA 582-600
(26), (14), (13), (8), (5), (3), (2), (2), (1)
(112), (31), (17), (1)
(78), (18), (16), (7)
(4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(101), (37), (25), (19), (18), (14), (11), (8), (4), (3), (2), (2), (1)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 50 μL
Shipping to United States ( )
Immunogen Synthetic peptide corresponding to amino acids 582-600 of human NOD2/CARD15
Specificity This antibody detects CARD15 / NOD2 (582-600). Also recognizes NOD2 alternatively spliced and mutated forms which contain the peptide immunogen sequence including NOD2 short, a 273 amino acid protein. Species Reactivity: Tested: Human
Purification Serum
Alternative Name CARD15 / NOD2 (NOD2 Antibody Abstract)
Background Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome, and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways, thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria, the induction of inflammatory responses, and the regulation of caspase activation and apoptosis. NOD2/CARD15 (caspase-recruitment domain 15) is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006, and Inohara et al. 2003). NOD2 is expressed in cells that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells, and epithelial cells (reviewed in Strober et al. 2006). NOD2 is a for thought to play a role in the pathogenesis of human gastrointestinal disease. Polymorphisms and mutations in NOD2 are associated with susceptibility to Crohn's disease, a chronic inflammatory bowel disease (Leung et al., 2006). Additionally, polymorphisms in NOD2 have also been found to be associated with Graft-versus-Host Disease (GVHD) (Holler et al., 2004). This association of NOD2 gene polymorphisms with gastrointestinal disease and GVHD suggests that NOD2 gene polymorphisms play a role in pro-inflammatory diseases. NOD2 is a 1040 amino acid protein.
Alternate names: Caspase recruitment domain-containing protein 15, IBD1, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2
Gene ID 64127
NCBI Accession NP_071445
UniProt Q9HC29
Research Area Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Leung, Hong, Fraser et al.: "Splicing of NOD2 (CARD15) RNA transcripts." in: Molecular immunology, Vol. 44, Issue 4, pp. 284-94, 2006 (PubMed).

Werts, Girardin, Philpott: "TIR, CARD and PYRIN: three domains for an antimicrobial triad." in: Cell death and differentiation, Vol. 13, Issue 5, pp. 798-815, 2006 (PubMed).

Strober, Murray, Kitani et al.: "Signalling pathways and molecular interactions of NOD1 and NOD2." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 9-20, 2006 (PubMed).

Holler, Rogler, Herfarth et al.: "Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation." in: Blood, Vol. 104, Issue 3, pp. 889-94, 2004 (PubMed).

Inohara, Nuñez: "NODs: intracellular proteins involved in inflammation and apoptosis." in: Nature reviews. Immunology, Vol. 3, Issue 5, pp. 371-82, 2003 (PubMed).

Catalog No. ABIN569245

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)