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Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 125-140) antibody

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AA 125-140
(26), (14), (13), (8), (5), (3), (2), (2), (1)
Dog (Canine), Human, Monkey, Pig (Porcine)
(112), (31), (17), (1)
(78), (18), (16), (7)
(4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunoprecipitation (IP), Western Blotting (WB)
(101), (37), (25), (19), (18), (14), (11), (8), (4), (3), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mL
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Immunogen Synthetic peptide corresponding to amino acids 125-140 of human Nod2
Specificity This antibody detects CARD15 / NOD2 (125-140). Species Reactivity: Tested: Chimpanzee, Human, Orangutan Expected from sequence similarity: Mouse, Rat, Pig, Dog, Cow, Rhesus Monkey
Purification Serum
Alternative Name CARD15 / NOD2 (NOD2 Antibody Abstract)
Background Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate apoptosis and/or NF-kB activation. Recently, Nod2, a third member of the family has been identified. Recent studies indicate that Nod2 activates NF-kB, but unlike Nod1, this new homologue is primary expressed in monocytes.
Alternate names: Caspase recruitment domain-containing protein 15, IBD1, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2
Gene ID 64127
NCBI Accession NP_071445
UniProt Q9HC29
Research Area Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Murillo, Crusius, van Bodegraven et al.: "CARD15 gene and the classification of Crohn's disease." in: Immunogenetics, Vol. 54, Issue 1, pp. 59-61, 2002 (PubMed).

Inohara, Ogura, Nuñez: "Nods: a family of cytosolic proteins that regulate the host response to pathogens." in: Current opinion in microbiology, Vol. 5, Issue 1, pp. 76-80, 2002 (PubMed).

Miceli-Richard, Lesage, Rybojad et al.: "CARD15 mutations in Blau syndrome." in: Nature genetics, Vol. 29, Issue 1, pp. 19-20, 2001 (PubMed).

Hugot, Chamaillard, Zouali et al.: "Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease." in: Nature, Vol. 411, Issue 6837, pp. 599-603, 2001 (PubMed).

Ogura, Inohara, Benito et al.: "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4812-8, 2001 (PubMed).

Catalog No. ABIN569246

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