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Details for Product No. ABIN569246

Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 125-140) antibody

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Antigen
Synonyms CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1, Card15, F830032C23Rik, Nlrc2
Epitope
»Alternatives AA 125-140
Reactivity
»Alternatives Dog (Canine), Human, Monkey, Pig (Porcine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN569246
Quantity 0.1 mL
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 125-140 of human Nod2
Sequence PHSLHPARDLQSHRPA
Specificity This antibody detects CARD15 / NOD2 (125-140). Species Reactivity: Tested: Chimpanzee, Human, Orangutan Expected from sequence similarity: Mouse, Rat, Pig, Dog, Cow, Rhesus Monkey
Purification Serum
Alternative Name CARD15 / NOD2
Background Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate apoptosis and/or NF-kB activation. Recently, Nod2, a third member of the family has been identified. Recent studies indicate that Nod2 activates NF-kB, but unlike Nod1, this new homologue is primary expressed in monocytes.
Alternate names: Caspase recruitment domain-containing protein 15, IBD1, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2
Gene ID 64127
NCBI Accession NP_071445.1
UniProt Q9HC29
Research Area Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Ogura, Inohara, Benito et al.: "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4812-8, 2001 (PubMed).

Hugot, Chamaillard, Zouali et al.: "Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease." in: Nature, Vol. 411, Issue 6837, pp. 599-603, 2001 (PubMed).

Miceli-Richard, Lesage, Rybojad et al.: "CARD15 mutations in Blau syndrome." in: Nature genetics, Vol. 29, Issue 1, pp. 19-20, 2001 (PubMed).

Inohara, Ogura, Nuñez: "Nods: a family of cytosolic proteins that regulate the host response to pathogens." in: Current opinion in microbiology, Vol. 5, Issue 1, pp. 76-80, 2002 (PubMed).

Murillo, Crusius, van Bodegraven et al.: "CARD15 gene and the classification of Crohn's disease." in: Immunogenetics, Vol. 54, Issue 1, pp. 59-61, 2002 (PubMed).

Alternatives for antigen "Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2)", type "Antibodies"
Hosts (66), (23), (6), (5)
Reactivities (93), (17), (12), (11), (11), (11), (4)
Applications (90), (32), (28), (26), (15), (9), (9), (9), (3), (1), (1), (1)
Conjugates (5), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (9), (8), (4), (2), (1), (1)
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