Nucleoporin 35kDa (NUP35) (AA 50-100) antibody

Details for Product No. ABIN569261
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Antigen
Epitope
AA 50-100
(13), (8), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Horse (Equine), Human, Monkey, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus), Zebrafish (Danio rerio)
(29), (7), (7), (3), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(30), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(31), (10), (8), (7), (6), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569261
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Immunogen Amino acids 50-100 of human NUP35 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, cow, horse, mouse, chimpanzee, dog and rat, 93% homologous in opossum, rhesus monkey, chicken, zebrafinch and Xenopus and 87% homologous in zebrafish and platypus.
Specificity This antibody detects NUP35. Species Reactivity: Tested: Chimpanzee, Cow, Dog, Horse, Human, Mouse, Rat Expected from sequence similarity: Chicken, Opossum, Rhesus Monkey, Xenopus, Zebrafish
Purification Antigen affinity chromatography
Alternative Name NUP35
Background Nucleoporin Nup35 or Mitotic phosphoprotein 44 is a nuclear protein known to be present on nuclear pore complex and is tightly associated with the nuclear membrane and lamina. This RNA associated protein belongs to the Nup53 family and has a MPPN (mitotic phosphoprotein N' end) domain. It has a small number of scattered phenylalanine-glycine repeats, but not the large domains seen in other nucleoporins. Though the exact function of NUP35 is yet to be revealed, it may function as a component of the nuclear pore complex (NPC) which are collectively referred to as nucleoporins (NUPs). It also may play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors, and may also play an important part in the association of MAD1, a transcriptional repressor with the NPC. NUP35 is widely expressed in most of the tissues.
Alternate names: 35 kDa nucleoporin, MP44, Mitotic phosphoprotein 44, NUP53, Nuclear pore complex protein Nup53, Nucleoporin NUP53, Nucleoporin Nup35
Gene ID 129401
NCBI Accession NP_612142
UniProt Q8NFH5
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Cronshaw, Krutchinsky, Zhang et al.: "Proteomic analysis of the mammalian nuclear pore complex." in: The Journal of cell biology, Vol. 158, Issue 5, pp. 915-27, 2002 (PubMed).

Hawryluk-Gara, Shibuya, Wozniak: "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex." in: Molecular biology of the cell, Vol. 16, Issue 5, pp. 2382-94, 2005 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

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