GATAD2B / Hp66 beta (AA 445-460) antibody

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AA 445-460
Human, Mouse (Murine)
Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN569276
Quantity 0.1 mg
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Immunogen Synthetic peptide corresponding to aa 445-460 of mouse p66b
Specificity This antibody detects GATAD2B / Hp66 beta. Species Reactivity: Tested: Human, mouse
Purification Protein G Chromatography
Background Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes (1-3). Increasing evidence indicates that recruitement of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. P66, a zinc finger-containing protein is one of the components of the MeCP1 complex (4). P66 and p68, the two components of MeCP1 are different forms of the same zinc finger-containing protein and are conserved from C.elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci (4).
Alternate names: GATA zinc finger domain-containing protein 2B, KIAA1150, Transcriptional repressor p66-beta, p66/p68
Gene ID 57459
NCBI Accession NP_065750.1
UniProt Q8WXI9
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Tong, Hassig, Schnitzler et al.: "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex." in: Nature, Vol. 395, Issue 6705, pp. 917-21, 1998 (PubMed).

Xue, Wong, Moreno et al.: "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities." in: Molecular cell, Vol. 2, Issue 6, pp. 851-61, 1999 (PubMed).

Zhang, Ng, Erdjument-Bromage et al.: "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation." in: Genes & development, Vol. 13, Issue 15, pp. 1924-35, 1999 (PubMed).

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