Tumor Protein P73 (TP73) (AA 95-104) antibody

Details for Product No. ABIN569278
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Antigen
Epitope
AA 95-104
(10), (9), (9), (7), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(91), (26), (20), (8), (2)
Host
Rabbit
(74), (24)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(86), (24), (22), (17), (15), (10), (10), (8), (5), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN569278
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Immunogen Synthetic peptide corresponding to amino acids 95-104 of human p73
Sequence CTHSPYAQPS S
Specificity This antibody detects Tumor protein p73 (TP73) (95-104). Species Reactivity: Tested: Chicken, Chimpanzee, Dog, New World monkey, Mouse, Rat
Purification Antigen affinity chromatography
Background P73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1). Tumor BioMarker: Vella et al (2003) found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.
Alternate names: p53-like transcription factor, p53-related protein
Gene ID 7161
NCBI Accession NP_001119712
UniProt O15350
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kaghad, Bonnet, Yang et al.: "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers." in: Cell, Vol. 90, Issue 4, pp. 809-19, 1997 (PubMed).

Ueda, Hijikata, Takagi et al.: "New p73 variants with altered C-terminal structures have varied transcriptional activities." in: Oncogene, Vol. 18, Issue 35, pp. 4993-8, 1999 (PubMed).

Yang, Walker, Bronson et al.: "p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours." in: Nature, Vol. 404, Issue 6773, pp. 99-103, 2000 (PubMed).

Levrero, De Laurenzi, Costanzo et al.: "The p53/p63/p73 family of transcription factors: overlapping and distinct functions." in: Journal of cell science, Vol. 113 ( Pt 10), pp. 1661-70, 2000 (PubMed).

Sayan, Sayan, Gogvadze et al.: "P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis." in: Oncogene, Vol. 27, Issue 31, pp. 4363-72, 2008 (PubMed).

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