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Details for Product No. ABIN569279

Tumor Protein P73 (TP73) (pTyr99), (AA 75-125) antibody

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Antigen
Synonyms P73, TAp73, zp73theta, TP73, tp73
Epitope
»Alternatives pTyr99, AA 75-125
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN569279
Quantity 20 µg
Price
500.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Amino acids 75-125, containing a phosphorylated tyrosine residue at position 99, of human p73 .Remarks: The amino acid sequence used is 100% homologous in human, mouse, rat, dog, chimp and monkey, and 90% homologous in chicken
Specificity This antibody detects Tumor protein p73 (TP73) pTyr99. Species Reactivity: Tested: Chicken, Chimpanzee, Dog, New World monkey, Mouse, Rat
Purification Antigen Affinity Chromatography
Background P73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1). 2. 7. Caspase-cleaved p73 fragments, including 55 kDa and 45 kDa, have been described (Sayan et al, 2008).
Alternate names: p53-like transcription factor, p53-related protein
Gene ID 7161
NCBI Accession NP_001119712.1
UniProt O15350
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kaghad, Bonnet, Yang et al.: "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers." in: Cell, Vol. 90, Issue 4, pp. 809-19, 1997 (PubMed).

Ueda, Hijikata, Takagi et al.: "New p73 variants with altered C-terminal structures have varied transcriptional activities." in: Oncogene, Vol. 18, Issue 35, pp. 4993-8, 1999 (PubMed).

Yang, Walker, Bronson et al.: "p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours." in: Nature, Vol. 404, Issue 6773, pp. 99-103, 2000 (PubMed).

Levrero, De Laurenzi, Costanzo et al.: "The p53/p63/p73 family of transcription factors: overlapping and distinct functions." in: Journal of cell science, Vol. 113 ( Pt 10), pp. 1661-70, 2000 (PubMed).

Sayan, Sayan, Gogvadze et al.: "P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis." in: Oncogene, Vol. 27, Issue 31, pp. 4363-72, 2008 (PubMed).

Alternatives for antigen "Tumor Protein P73 (TP73)", type "Antibodies"
Hosts (71), (33)
Reactivities (97), (39), (26), (8), (2)
Applications (92), (32), (28), (24), (12), (10), (9), (8), (8), (5), (4), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (9), (8), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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