Protein Kinase D2 (PKD2) (AA 170-210) antibody

Details for Product No. ABIN569312
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AA 170-210
(20), (15), (7), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Horse (Equine), Human, Monkey, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus)
(114), (8), (6), (3), (3)
(76), (32), (7)
(5), (5), (5), (5), (5), (5)
Western Blotting (WB)
(95), (48), (44), (25), (25), (23), (9), (6), (5), (4), (4), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN569312
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Immunogen Amino acids 170-210 of human PKD2 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, chimpanzee, dog, horse, mouse, opossum, rat, 94% homologous in cow and 77% homologous in zebrafish
Specificity This antibody detects PRKD2 / PKD2. Species Reactivity: Tested: Chimpanzee, Dog, Horse, Human, Mouse, Opossum, Rat Expected from sequence similarity: Cow, Zebrafish
Purification Protein A chromatography
Alternative Name PRKD2 / PKD2
Background PKD2 is a novel serine/threonine protein kinase belonging to protein kinase superfamily, PKD subfamily and contains a PH domain, two phorbol-ester/DAG-type zinc fingers and a protein kinase domain. PKD2 is a calcium independent, phospholipid dependent, protein kinase activated by growth factors, diacylglycerol, phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. Thus helps in controlling phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling. PKD2 can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN and also controls the release of secretory granules in neuroendocrine tumor cells at the level of the Golgi apparatus. PKD2 helps in the proliferation and invasion of carcinoid tumors and is widely expressed in most of the tissues.
Alternate names: HSPC187, PKC-D2, Serine/threonine-protein kinase D2, nPKC-D2
Gene ID 25865
NCBI Accession NP_001073349
UniProt Q9BZL6
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Chen, Deng, Li et al.: "Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family." in: The Biochemical journal, Vol. 411, Issue 2, pp. 333-42, 2008 (PubMed).

Greenman, Stephens, Smith et al.: "Patterns of somatic mutation in human cancer genomes. ..." in: Nature, Vol. 446, Issue 7132, pp. 153-8, 2007 (PubMed).

Sturany, Van Lint, Muller et al.: "Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3310-8, 2001 (PubMed).

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