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RAD17 Homolog (S. Pombe) (RAD17) (pSer645) antibody

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(27), (16), (15), (12), (7), (7), (5), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Horse (Equine), Human, Monkey, Mouse (Murine)
(145), (57), (43), (3), (2), (2), (2)
(132), (12), (11), (1)
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(130), (45), (22), (18), (18), (15), (13), (6), (3), (2), (1), (1)
Pubmed 3 references available
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Quantity 20 μg
Shipping to United States ( )
Immunogen Human Rad17 protein containing a phosphorylated serine residue at position 645 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a, CRA_f and CRA_d), rhesus monkey, chimpanzee and orangutan, 92% homologous in horse, cow and mouse and 85% homologous in dog and rat.
Specificity This antibody detects RAD17 pSer645. Species Reactivity: Tested: Chimpanzee, Human, Mouse, Orangutan, Rhesus Monkey Expected from sequence similarity: Cow, Dog, Horse, Rat
Purification Antigen affinity chromatography
Alternative Name RAD17 (RAD17 Antibody Abstract)
Background Rad17, also known as 'cell cycle checkpoint protein RAD17,' is a nuclear protein belonging to the Rad17/RAD24 family and necessary for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Rad17 is known to have a weak ATPase activity and is required for binding to chromatin and also participates in the recruitment of the RAD1-RAD9-HUS1 complex onto chromatin, and in CHEK1 activation. It may also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. Rad17 is a part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Four isoforms have been reported by X-ray irradiation. Overexpression of this protein is seen in various cancer cell lines and in colon carcinoma.
Alternate names: Cell cycle checkpoint protein RAD17, R24L, RF-C/activator 1 homolog
Gene ID 5884
NCBI Accession NP_002864
UniProt O75943
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Bao, Tibbetts, Brumbaugh et al.: "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses." in: Nature, Vol. 411, Issue 6840, pp. 969-74, 2001 (PubMed).

Bao, Chang, Auclair et al.: "HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma." in: Cancer research, Vol. 59, Issue 9, pp. 2023-8, 1999 (PubMed).

Parker, Van de Weyer, Laus et al.: "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene." in: The Journal of biological chemistry, Vol. 273, Issue 29, pp. 18340-6, 1998 (PubMed).

Catalog No. ABIN569330

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