Regenerating Islet-Derived 3 alpha (REG3A) (AA 1-50), (N-Term) antibody

Details for Product No. ABIN569339
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Antigen
Epitope
AA 1-50, N-Term
(12), (9), (8), (4), (3), (2), (2), (2), (2), (1)
Reactivity
Human, Monkey
(58), (16), (14), (12), (12), (1)
Host
Rabbit
(52), (5), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(38), (23), (10), (10), (10), (7), (5), (3), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN569339
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Immunogen Amino acids 1-50 of human REG3A .Remarks: The amino acid sequence used as immunogen is 100% homologous in human and chimpanzee, 86% homologous in rhesus monkey and 73% homologous in bovine and human REG3G.
Specificity This antibody detects REG3A. Species Reactivity: Tested: Chimpanzee, Human Expected from sequence similarity: Bovine, Rhesus Monkey
Purification Protein G Chromatography
Alternative Name REG3A
Background REG3A, also known as Regenerating islet-derived protein 3 alpha, Reg III-alpha, and pancreatitis associated protein, is a 174 amino acid containing stress protein involved in the control of bacterial proliferation. This secreted protein is generally found in the apical region of pancreatic acinar cells and appears in pancreatic juice after induction of pancreatic inflammation. It has a possible role in inducing new pancreatic islets development. REG3A belongs to the Reg-related family with a C-type lectin domain and is constitutively expressed in intestine while low expression is found in healthy pancreas. Overexpression of REG3A is seen during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
Alternate names: HIP, Human proislet peptide, PAP, PAP1, Pancreatitis-associated protein 1, REG-3-alpha, Reg III-alpha, Regenerating islet-derived protein 3-alpha, Regenerating islet-derived protein III-alpha
Gene ID 5068
NCBI Accession NP_002571
UniProt Q06141
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications He, Tessier-Lavigne: "Neuropilin is a receptor for the axonal chemorepellent Semaphorin III." in: Cell, Vol. 90, Issue 4, pp. 739-51, 1997 (PubMed).

Kolodkin, Levengood, Rowe et al.: "Neuropilin is a semaphorin III receptor." in: Cell, Vol. 90, Issue 4, pp. 753-62, 1997 (PubMed).

Soker, Takashima, Miao et al.: "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor." in: Cell, Vol. 92, Issue 6, pp. 735-45, 1998 (PubMed).

Tokunaga, Yamazaki, Morita: "Localization of heparin- and neuropilin-1-recognition sites of viral VEGFs." in: Biochemical and biophysical research communications, Vol. 348, Issue 3, pp. 957-62, 2006 (PubMed).

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