Resistin (RETN) (AA 94-102) antibody

Details for Product No. ABIN569343
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Antigen
Synonyms ADSF, FIZZ3, RETN1, RSTN, XCP1, Rstn, Xcp4, Fizz3, RETN
Epitope
AA 94-102
(11), (10), (7), (7), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(133), (53), (27), (12), (2), (1)
Host
Rabbit
(123), (33), (28), (5), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(22), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(136), (128), (27), (20), (18), (18), (13), (7), (6), (5), (4), (3), (2), (2), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN569343
Quantity 0.1 mg
Price
423.50 $   Plus shipping costs $45.00
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Immunogen Peptide corresponding to amino acids 94-102 of human Resistin
Sequence AGMDWTGAR
Specificity This antibody detects Resistin / RETN. Species Reactivity: Tested: Human
Purification Protein G purified
Alternative Name Resistin
Background RELM/FIZZ family of proteins are Cysteine-rich proteins consist of a highly conserved C- terminal cysteine rich domain and play a vital role in regulation of adipogenesis and insulin resistance. Resistin, a human homolog of mouse resistin, is a novel member of this family. It is a 12KDa adipokine which is produced by both brown and white adipose tissue and is mainly secreted by adipocytes. Its levels are down-regulated by insulin and have been shown to be elevated during Type 2 diabetes, indicating a critical role in regulating adipogenesis and insulin resistance. It promotes aortic smooth muscle cell proliferation through activation of ERK1/2 and PI3/Akt signaling pathways. It is expressed in macrophages and functions as a pro-inflammatory cytokine by up-regulating IL-6 and activating NF-kappaB signaling pathway. Its expression is regulated by numerous factors which include PPAR-alpha, Insulin, Growth and gonadal hormones, TNF-alpha, Endothelin-1 and certain pro-inflammatory cytokines like IL-6.
Alternate names: ADSF, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine- rich secreted protein FIZZ3, FIZZ3, HXCP1, RETN, RSTN
Gene ID 56729
NCBI Accession NP_001180303.1
UniProt Q9HD89
Research Area Cardiovascular, Atherosclerosis, Metabolism, Hormones
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Steppan, Bailey, Bhat et al.: "The hormone resistin links obesity to diabetes." in: Nature, Vol. 409, Issue 6818, pp. 307-12, 2001 (PubMed).

Banerjee, Lazar: "Dimerization of resistin and resistin-like molecules is determined by a single cysteine." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25970-3, 2001 (PubMed).

Hartman, Hu, Tyler et al.: "Mechanisms regulating adipocyte expression of resistin." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19754-61, 2002 (PubMed).

Bokarewa, Nagaev, Dahlberg et al.: "Resistin, an adipokine with potent proinflammatory properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5789-95, 2005 (PubMed).

Hosts (123), (33), (28), (5), (4), (3)
Reactivities (133), (53), (27), (12), (2), (1)
Applications (136), (128), (27), (20), (18), (18), (13), (7), (6), (5), (4), (3), (2), (2), (2), (1), (1)
Conjugates (22), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (11), (10), (7), (7), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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