anti-Resistin antibody (RETN) (AA 79-90)

Details for Product anti-RETN Antibody No. ABIN569344
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Antigen
Epitope
AA 79-90
(15), (12), (11), (10), (10), (9), (9), (8), (6), (6), (5), (5), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(190), (93), (46), (4), (2), (1)
Host
Rabbit
(187), (54), (41), (8), (6), (6)
Clonality
Polyclonal
Conjugate
This Resistin antibody is un-conjugated
(36), (11), (11), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(227), (197), (57), (32), (24), (20), (13), (13), (13), (11), (7), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Immunogen Peptide corresponding to amino acids 79-90 of human Resistin
Sequence GSWDVRAETT CH
Specificity This antibody detects Resistin / RETN. Species Reactivity: Tested: Human
Purification Protein G purified
Alternative Name Resistin (RETN Antibody Abstract)
Background RELM/FIZZ family of proteins are Cysteine-rich proteins consist of a highly conserved C- terminal cysteine rich domain and play a vital role in regulation of adipogenesis and insulin resistance. Resistin, a human homolog of mouse resistin, is a novel member of this family. It is a 12KDa adipokine which is produced by both brown and white adipose tissue and is mainly secreted by adipocytes. Its levels are down-regulated by insulin and have been shown to be elevated during Type 2 diabetes, indicating a critical role in regulating adipogenesis and insulin resistance. It promotes aortic smooth muscle cell proliferation through activation of ERK1/2 and PI3/Akt signaling pathways. It is expressed in macrophages and functions as a pro-inflammatory cytokine by up-regulating IL-6 and activating NF-kappaB signaling pathway. Its expression is regulated by numerous factors which include PPAR-alpha, Insulin, Growth and gonadal hormones, TNF-alpha, Endothelin-1 and certain pro-inflammatory cytokines like IL-6.
Alternate names: ADSF, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine- rich secreted protein FIZZ3, FIZZ3, HXCP1, RETN, RSTN
Gene ID 56729
NCBI Accession NP_001180303
UniProt Q9HD89
Research Area Cardiovascular, Atherosclerosis, Metabolism, Hormones
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Bokarewa, Nagaev, Dahlberg et al.: "Resistin, an adipokine with potent proinflammatory properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5789-95, 2005 (PubMed).

Patel, Buckels, Kinghorn et al.: "Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators." in: Biochemical and biophysical research communications, Vol. 300, Issue 2, pp. 472-6, 2002 (PubMed).

Hartman, Hu, Tyler et al.: "Mechanisms regulating adipocyte expression of resistin." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19754-61, 2002 (PubMed).

Shuldiner, Yang, Gong: "Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ." in: The New England journal of medicine, Vol. 345, Issue 18, pp. 1345-6, 2001 (PubMed).

Banerjee, Lazar: "Dimerization of resistin and resistin-like molecules is determined by a single cysteine." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25970-3, 2001 (PubMed).

Kim, Lee, Moon et al.: "A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11252-6, 2001 (PubMed).

Steppan, Bailey, Bhat et al.: "The hormone resistin links obesity to diabetes." in: Nature, Vol. 409, Issue 6818, pp. 307-12, 2001 (PubMed).

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