Resistin (RETN) (AA 79-90) antibody

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AA 79-90
(15), (12), (11), (11), (10), (9), (9), (9), (8), (6), (6), (5), (5), (4), (2), (1), (1), (1), (1)
(203), (87), (44), (4), (2), (1)
(193), (55), (45), (9), (6), (5)
(36), (11), (11), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Western Blotting (WB)
(227), (206), (54), (34), (22), (20), (13), (13), (10), (9), (6), (5), (5), (4), (4), (2), (2), (2), (2), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN569344
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Immunogen Peptide corresponding to amino acids 79-90 of human Resistin
Specificity This antibody detects Resistin / RETN. Species Reactivity: Tested: Human
Purification Protein G purified
Alternative Name Resistin
Background RELM/FIZZ family of proteins are Cysteine-rich proteins consist of a highly conserved C- terminal cysteine rich domain and play a vital role in regulation of adipogenesis and insulin resistance. Resistin, a human homolog of mouse resistin, is a novel member of this family. It is a 12KDa adipokine which is produced by both brown and white adipose tissue and is mainly secreted by adipocytes. Its levels are down-regulated by insulin and have been shown to be elevated during Type 2 diabetes, indicating a critical role in regulating adipogenesis and insulin resistance. It promotes aortic smooth muscle cell proliferation through activation of ERK1/2 and PI3/Akt signaling pathways. It is expressed in macrophages and functions as a pro-inflammatory cytokine by up-regulating IL-6 and activating NF-kappaB signaling pathway. Its expression is regulated by numerous factors which include PPAR-alpha, Insulin, Growth and gonadal hormones, TNF-alpha, Endothelin-1 and certain pro-inflammatory cytokines like IL-6.
Alternate names: ADSF, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine- rich secreted protein FIZZ3, FIZZ3, HXCP1, RETN, RSTN
Gene ID 56729
NCBI Accession NP_001180303
UniProt Q9HD89
Research Area Cardiovascular, Atherosclerosis, Metabolism, Hormones
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Bokarewa, Nagaev, Dahlberg et al.: "Resistin, an adipokine with potent proinflammatory properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5789-95, 2005 (PubMed).

Patel, Buckels, Kinghorn et al.: "Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators." in: Biochemical and biophysical research communications, Vol. 300, Issue 2, pp. 472-6, 2002 (PubMed).

Hartman, Hu, Tyler et al.: "Mechanisms regulating adipocyte expression of resistin." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19754-61, 2002 (PubMed).

Shuldiner, Yang, Gong: "Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ." in: The New England journal of medicine, Vol. 345, Issue 18, pp. 1345-6, 2001 (PubMed).

Banerjee, Lazar: "Dimerization of resistin and resistin-like molecules is determined by a single cysteine." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25970-3, 2001 (PubMed).

Kim, Lee, Moon et al.: "A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11252-6, 2001 (PubMed).

Steppan, Bailey, Bhat et al.: "The hormone resistin links obesity to diabetes." in: Nature, Vol. 409, Issue 6818, pp. 307-12, 2001 (PubMed).

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