Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN569353

RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Epitope
»Alternatives AA 1-50, N-Term
Reactivity
»Alternatives Human, Monkey, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN569353
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen A portion of amino acids 1-50 of human RORgamma .Remarks: The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a) and chimpanzee, 96% homologous in dog, 92% homologous in mouse and rat and 88% homologous in cow.
Specificity This antibody will detect RORg and may detect RORgt, but can not be used to distinguish between the two proteins. Species Reactivity: Tested: Chimpanzee, Human Expected from sequence similarity: Mouse, Rat, Dog, Cow
Purification Antigen Affinity Chromatography
Alternative Name ROR-gamma / RORC
Background ROR-gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR- gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR-gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
Alternate names: NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RORG, RZRG, Retinoid-related orphan receptor-gamma
Gene ID 6097
NCBI Accession NP_001001523.1
UniProt P51449
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Hirose, Smith, Jetten: "ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle." in: Biochemical and biophysical research communications, Vol. 205, Issue 3, pp. 1976-83, 1995 (PubMed).

Kurebayashi, Ueda, Sakaue et al.: "Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10132-7, 2000 (PubMed).

Eberl, Marmon, Sunshine et al.: "An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells." in: Nature immunology, Vol. 5, Issue 1, pp. 64-73, 2003 (PubMed).

Ivanov, McKenzie, Zhou et al.: "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells." in: Cell, Vol. 126, Issue 6, pp. 1121-33, 2006 (PubMed).

Alternatives for antigen "RAR-Related Orphan Receptor C (RORC)", type "Antibodies"
Hosts (83), (22), (6), (2)
Reactivities (104), (60), (31), (31), (29), (25), (13), (6), (1), (1), (1), (1)
Applications (71), (30), (23), (20), (13), (6), (3), (2), (1)
Conjugates (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (20), (11), (10), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Beacon