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TBK1 Binding Protein 1 (TBKBP1) (AA 300-350) antibody

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AA 300-350
(25), (17), (8), (8), (6), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(29), (27), (9)
(3), (3), (3), (3), (3), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(43), (29), (11), (4), (3), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen Amino acids 300-350 of human SINTBAD/TBKBP1 .Remarks: The amino acid sequence used as immunogen is 100% homologous in human and 85% homologous in mouse and rat.
Specificity This antibody detects SINTBAD/TBKBP1. Species Reactivity: Tested: Human, Mouse, Rat
Purification Antigen affinity chromatography
Alternative Name TBKBP1 (TBKBP1 Antibody Abstract)
Background SINTBAD is an adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It is essential for signal transduction during viral infection and plays a major role in the NF-kB pathway. SINTBAD is thus required for efficient IRF (interferon regulatory factor) activation by Sendai virus. The protein binds TBK1 (TANK-binding kinase) and IKKi (inhibitor of nuclear factor B kinase, inducible) via a newly identified TBK1/IKKi-binding domain (TBD), which it shares with TANK and NAP1. Binding to kinases via TBD is essential for IRF3 (interferon regulatory factor 3) activation which controls the expression of antiviral genes during infection. The protein has a ubiquitous expression with highest levels in ovary, followed by testis and brain. Human SINTBAD gene is mapped to chromosome 17q21.32.
Alternate names: KIAA0775, ProSAPiP2, Sintbad, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1
Gene ID 9755
NCBI Accession NP_055541
UniProt A7MCY6
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Ryzhakov, Randow: "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK." in: The EMBO journal, Vol. 26, Issue 13, pp. 3180-90, 2007 (PubMed).

Bouwmeester, Bauch, Ruffner et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. ..." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, 2004 (PubMed).

Nagase, Ishikawa, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, 1999 (PubMed).

Catalog No. ABIN569411

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