Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 808-826) antibody

Details for Product No. ABIN569456
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Antigen
Epitope
AA 808-826
(45), (33), (19), (12), (7), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(239), (99), (90), (15), (12), (8), (4)
Host
Rabbit
(202), (49), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(188), (81), (76), (53), (39), (30), (19), (15), (14), (6), (5), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Discontinued
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Catalog No. ABIN569456
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Immunogen Synthetic peptide corresponding to amino acids 808-826 of Human STAT6
Specificity This antibody detects STAT6. Species Reactivity: Tested: Human, Mouse, Rat.
Purification Protein G Chromatography
Alternative Name STAT6
Background STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT6 is rapidly activated in response to IL-4, however the fate of the activated form is not clear.
Alternate names: IL-4 Stat, Signal transducer and activator of transcription 6
Gene ID 6778
NCBI Accession NP_001171549
UniProt P42226
Research Area Chromatin and Nuclear Signaling, Signaling, Receptors, Inflammation
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Schindler, Darnell: "Transcriptional responses to polypeptide ligands: the JAK-STAT pathway." in: Annual review of biochemistry, Vol. 64, pp. 621-51, 1995 (PubMed).

Quelle, Shimoda, Thierfelder et al.: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995 (PubMed).

Bluyssen, Levy: "Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA." in: The Journal of biological chemistry, Vol. 272, Issue 7, pp. 4600-5, 1997 (PubMed).

Darnell: "STATs and gene regulation." in: Science (New York, N.Y.), Vol. 277, Issue 5332, pp. 1630-5, 1997 (PubMed).

Leonard, OShea: "Jaks and STATs: biological implications." in: Annual review of immunology, Vol. 16, pp. 293-322, 1998 (PubMed).

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