Transmembrane Protein 173 (TMEM173) (AA 310-360) antibody

Details for Product No. ABIN569459
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Antigen
Synonyms RGD1562552, STING, 2610307O08Rik, ERIS, MPYS, Mita, MITA, NET23
Epitope
AA 310-360
(12), (4), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
(57), (24), (15), (12), (12), (12)
Host
Rabbit
(40), (20)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(37), (28), (14), (11), (10), (7), (6), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN569459
Quantity 0.1 mg
Price
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Immunogen Amino acids 310-360 of human STING .Remarks: The amino acid sequence used as immunogen is 100% homologous in human, rhesus monkey and chimpanzee, 94% homologous in mouse and rat, 87% homologous in dog and 81% homologous in horse.
Specificity This antibody detects TMEM173 / STING. Species Reactivity: Tested: Chimpanzee, Human, Mouse, Rat, Rhesus Monkey Expected from sequence similarity: Horse, Dog
Purification Protein A chromatography
Alternative Name TMEM173 / STING
Background STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF- kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN- alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
Alternate names: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
Gene ID 340061
NCBI Accession NP_938023.1
UniProt Q86WV6
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Jin, Waterman, Jonscher et al.: "MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals." in: Molecular and cellular biology, Vol. 28, Issue 16, pp. 5014-26, 2008 (PubMed).

Ishikawa, Barber: "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling." in: Nature, Vol. 455, Issue 7213, pp. 674-8, 2008 (PubMed).

Hosts (40), (20)
Reactivities (57), (24), (15), (12), (12), (12)
Applications (37), (28), (14), (11), (10), (7), (6), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (4), (2), (1), (1), (1), (1), (1)
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