Transmembrane Protein 173 (TMEM173) (AA 50-100) antibody

Details for Product No. ABIN569460
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AA 50-100
(26), (16), (4), (2), (2), (1), (1), (1), (1)
Chimpanzee, Human, Rhesus Monkey
(70), (25), (15)
(60), (12)
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(55), (28), (23), (15), (14), (10), (10), (7), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN569460
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Immunogen Amino acids 50-100 of human STING .Remarks: The amino acid sequence used as immunogen is 100% homologous in human (isoform CRA_a), 93% homologous in rhesus monkey and chimpanzee, 83% homologous in cow and horse and 77% homologous in boar.
Specificity This antibody detects TMEM173 / STING. Species Reactivity: Tested: Human Expected from sequence similarity: Horse, Chimpanzee, Cow, Rhesus Monkey
Purification Antigen Affinity Chromatography
Alternative Name TMEM173 / STING
Background STING is a signaling protein and an important component of innate immune signaling. This protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Expression is ubiquitous in most tissues and is present on the endoplasmic reticulum membrane, cell membrane and outer membrane of mitochondrion.
Alternate names: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
Gene ID 340061
NCBI Accession NP_938023
UniProt Q86WV6
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Ishikawa, Barber: "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling." in: Nature, Vol. 455, Issue 7213, pp. 674-8, 2008 (PubMed).

Jin, Waterman, Jonscher et al.: "MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals." in: Molecular and cellular biology, Vol. 28, Issue 16, pp. 5014-26, 2008 (PubMed).

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