Transmembrane Protein 173 (TMEM173) (AA 50-100) antibody

Details for Product No. ABIN569460
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Antigen
Epitope
AA 50-100
(25), (16), (2), (2), (1), (1), (1), (1)
Reactivity
Chimpanzee, Human, Rhesus Monkey
(71), (25), (15), (12), (12), (12)
Host
Rabbit
(53), (20)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (38), (21), (14), (12), (11), (10), (4), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN569460
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Immunogen Amino acids 50-100 of human STING .Remarks: The amino acid sequence used as immunogen is 100% homologous in human (isoform CRA_a), 93% homologous in rhesus monkey and chimpanzee, 83% homologous in cow and horse and 77% homologous in boar.
Specificity This antibody detects TMEM173 / STING. Species Reactivity: Tested: Human Expected from sequence similarity: Horse, Chimpanzee, Cow, Rhesus Monkey
Purification Antigen Affinity Chromatography
Alternative Name TMEM173 / STING
Background STING is a signaling protein and an important component of innate immune signaling. This protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Expression is ubiquitous in most tissues and is present on the endoplasmic reticulum membrane, cell membrane and outer membrane of mitochondrion.
Alternate names: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
Gene ID 340061
NCBI Accession NP_938023
UniProt Q86WV6
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Jin, Waterman, Jonscher et al.: "MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals." in: Molecular and cellular biology, Vol. 28, Issue 16, pp. 5014-26, 2008 (PubMed).

Ishikawa, Barber: "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling." in: Nature, Vol. 455, Issue 7213, pp. 674-8, 2008 (PubMed).

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