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Toll-Like Receptor 3 (TLR3) (AA 750-800) antibody

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AA 750-800
(41), (30), (13), (13), (6), (6), (6), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Macaque, Gorilla, Cow (Bovine), Dog (Canine), Chimpanzee, Horse (Equine), Cat (Feline), Human, Mouse (Murine), Pig (Porcine), Rhesus Monkey
(222), (146), (48), (19), (3), (1), (1), (1), (1)
(187), (102), (16), (4), (2)
(30), (25), (21), (10), (7), (6), (5), (5), (4), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(187), (103), (95), (59), (57), (31), (28), (28), (19), (11), (9), (6), (5), (4), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen Amino acids 750-800 of Human TLR3 .Remarks: The amino acid sequence used as immunogen is 100% homologous in Human, Rhesus Monkey, Chimpanzee, Macaque and Gorilla, 92% homologous in Cat, Dog, Cow, Horse and Pig and 84% homologous in Mouse.
Specificity This antibody detects CD283 / TLR3. Species Reactivity: Tested: Chimpanzee, Gorilla, Human, Macaque, Rhesus Monkey Expected from sequence similarity: Cat, Cow, Dog, Horse, Mouse, Rat
Purification Antigen affinity chromatography
Alternative Name CD283 / TLR3 (TLR3 Antibody Abstract)
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor- associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
Alternate names: Toll-like receptor 3
Gene ID 9606
UniProt O15455
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Chuang, Ulevitch: "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells." in: Biochimica et biophysica acta, Vol. 1518, Issue 1-2, pp. 157-61, 2001 (PubMed).

Muzio, Bosisio, Polentarutti et al.: "Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 11, pp. 5998-6004, 2000 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Rock, Hardiman, Timans et al.: "A family of human receptors structurally related to Drosophila Toll." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 2, pp. 588-93, 1998 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Catalog No. ABIN569488

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