Toll-Like Receptor 3 (TLR3) (pTyr759), (AA 750-800) antibody

Details for Product No. ABIN569489
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Antigen
Epitope
pTyr759, AA 750-800
(26), (20), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(175), (118), (63), (45), (12), (4), (1), (1), (1)
Host
Rabbit
(118), (86), (7), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(24), (11), (9), (9), (9), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(136), (86), (65), (56), (40), (27), (19), (15), (15), (10), (5), (1), (1)
Pubmed 7 references available
Quantity 20 μg
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Catalog No. ABIN569489
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Immunogen Amino acids 750-800, containing a phosphorylated tyrosine residue at position 759, of human TLR3
Specificity This antibody detects CD283 / TLR3 pTyr759. Species Reactivity: Tested: Human Expected from sequence similarity: Bovine, Chimpanzee, Dog, Mouse, New World monkey, Rat
Purification Antigen affinity chromatography
Alternative Name CD283 / TLR3
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor- associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa (4). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
Alternate names: Toll-like receptor 3
Gene ID 9606
UniProt O15455
Research Area Signaling, Immunology, Inflammation
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Kammeraat, Veldstra: "Characterization of succinate semialdehyde dehydrogenase from rat brain." in: Biochimica et biophysica acta, Vol. 151, Issue 1, pp. 1-10 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).

Rock, Hardiman, Timans et al.: "A family of human receptors structurally related to Drosophila Toll." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 2, pp. 588-93, 1998 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Muzio, Polentarutti, Bosisio et al.: "Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes." in: Journal of leukocyte biology, Vol. 67, Issue 4, pp. 450-6, 2000 (PubMed).

Muzio, Bosisio, Polentarutti et al.: "Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 11, pp. 5998-6004, 2000 (PubMed).

Sarkar, Peters, Elco et al.: "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling." in: Nature structural & molecular biology, Vol. 11, Issue 11, pp. 1060-7, 2004 (PubMed).

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