anti-TRAF1 antibody (TNF Receptor-Associated Factor 1) (AA 51-69)

Details for Product anti-TRAF1 Antibody No. ABIN569503
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AA 51-69
(15), (15), (15), (12), (11), (7), (3), (3), (2), (2), (1), (1), (1)
Mouse (Murine)
(78), (34), (20), (3), (3), (2), (1), (1), (1)
(55), (17), (11), (4)
This TRAF1 antibody is un-conjugated
(4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(72), (39), (14), (10), (10), (7), (6), (4), (4), (3), (1)
Pubmed 2 references available
Quantity 50 μL
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Immunogen Synthetic peptide corresponding to amino acids 51-69 of mouse TRAF1
Specificity This antibody recognizes TRAF1, Mouse TRAF1 is a 409 amino acid protein. Species Reactivity: Tested: Mouse
Purification Serum
Alternative Name TRAF1 / EBI6 (TRAF1 Antibody Abstract)
Background The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
Alternate names: Epstein-Barr virus-induced protein 6, TNF receptor-associated factor 1
Gene ID 10090
UniProt P39428
Pathways NF-kappaB Signaling, Apoptosis
Restrictions For Research Use only
Format Liquid
Buffer 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Rao, Ghosh, Douillard et al.: "An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn." in: Signal transduction, Vol. 2, Issue 1-2, pp. 29-39, 2010 (PubMed).

Chung, Park, Ye et al.: "All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 679-88, 2002 (PubMed).

Catalog No. ABIN569503
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