TNF Receptor-Associated Factor 2 (TRAF2) (AA 87-106) antibody

Details for Product No. ABIN569504
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Antigen
Epitope
AA 87-106
(23), (12), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(98), (46), (39), (4)
Host
Rabbit
(76), (20), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(89), (45), (31), (24), (15), (10), (8), (7), (5), (4), (2)
Pubmed 2 references available
Quantity 50 µL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569504
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Immunogen Synthetic peptide corresponding to amino acids 87-106 of human TRAF2
Sequence SSSAFPDNAA RREVESLPAV
Specificity This antibody detects TRAF2 / TRAP3.
Purification Serum
Alternative Name TRAF2 / TRAP3
Background The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. TRAF2 is typically described as a 501 amino acid (aa) protein, GenBank no. NP_066961.2. However, various TRAF2 isoforms have been described. Therefore the molecular weight of TRAF2 detected by Western blot may vary depending on isoforms expressed, please see the Application Notes for additional details.
Alternate names: TNF receptor-associated factor 2, Tumor necrosis factor type 2 receptor-associated protein 3
Gene ID 7186
NCBI Accession NP_066961
UniProt Q12933
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Chung, Park, Ye et al.: "All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 679-88, 2002 (PubMed).

Rao, Ghosh, Douillard et al.: "An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn." in: Signal transduction, Vol. 2, Issue 1-2, pp. 29-39, 2010 (PubMed).

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