TNF Receptor-Associated Factor 3 (TRAF3) (AA 5-25) antibody

Details for Product No. ABIN569507
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Antigen
Epitope
AA 5-25
(18), (12), (12), (8), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(86), (49), (35)
Host
Rabbit
(81), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(76), (28), (18), (10), (9), (9), (9), (8), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 50 μL
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Immunogen Synthetic peptide corresponding to amino acis 5-25 of human TRAF3
Sequence KKMDSPGALQ TNPPLKLHTD R
Specificity This antibody detects TRAF3 / CRAF1. Species Reactivity: Tested: Human
Purification Serum
Alternative Name TRAF3 / CRAF1 (TRAF3 Antibody Abstract)
Background The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
Alternate names: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3
Gene ID 7187
NCBI Accession NP_001186356
UniProt Q13114
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Rao, Ghosh, Douillard et al.: "An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn." in: Signal transduction, Vol. 2, Issue 1-2, pp. 29-39, 2010 (PubMed).

Chung, Park, Ye et al.: "All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 679-88, 2002 (PubMed).

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Catalog No. ABIN569507
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