TNF Receptor-Associated Factor 6 (TRAF6) (AA 451-469) antibody

Details for Product No. ABIN569511
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Antigen
Synonyms
RNF85, MGC:3310, AI851288, 2310003F17Rik, C630032O20Rik, rnf85, traf6, xtraf6, CG10961, DTRAF2, Dmel\\CG10961, TRAF, TRAF2, TRAF6, Traf2, dTRAF2, dTRAF6, dTraf2, dtraf2, GB10539, fi15f02, wu:fi15f02,  ... show more
RNF85, MGC:3310, AI851288, 2310003F17Rik, C630032O20Rik, rnf85, traf6, xtraf6, CG10961, DTRAF2, Dmel\\CG10961, TRAF, TRAF2, TRAF6, Traf2, dTRAF2, dTRAF6, dTraf2, dtraf2, GB10539, fi15f02, wu:fi15f02, zgc:63704 show less
Epitope
AA 451-469
(18), (7), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(84), (49), (45), (3), (1), (1)
Host
Rabbit
(86), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(80), (29), (25), (19), (14), (14), (14), (10), (3), (3), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN569511
Quantity 50 µL
Price
456.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide corresponding to amino acids 451-469 of human TRAF6
Sequence DAKPELLAFQRPTIPRNPK
Specificity This antibody detects TRAF6 / RNF85. Species Reactivity: Tested: Cow, Human, Mouse, Rat
Purification Serum
Alternative Name TRAF6 / RNF85
Background The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.
Alternate names: Interleukin-1 signal transducer, RING finger protein 85, TNF receptor-associated factor 6
Gene ID 7189
NCBI Accession NP_004611.1
UniProt Q9Y4K3
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Chung, Park, Ye et al.: "All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 679-88, 2002 (PubMed).

Rao, Ghosh, Douillard et al.: "An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn." in: Signal transduction, Vol. 2, Issue 1-2, pp. 29-39, 2010 (PubMed).

Hosts (86), (7), (1)
Reactivities (84), (49), (45), (3), (1), (1)
Applications (80), (29), (25), (19), (14), (14), (14), (10), (3), (3), (2), (2), (2), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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