Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 161-177) antibody

Details for Product No. ABIN569514
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Antigen
Synonyms ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Ly109l, OPG, Trance, TNFSF11
Epitope
AA 161-177
(8), (8), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(110), (92), (32), (25), (13), (1), (1)
Host
Rabbit
(110), (26), (20), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(22), (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(120), (79), (35), (28), (20), (19), (14), (13), (8), (6), (5), (5), (3), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN569514
Quantity 0.1 mg
Price
456.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide corresponding to amino acids 161-177 of mouse Trance
Sequence AQPFAHLTINAASIPSG
Specificity This antibody detects CD254 / RANKL / TRANCE. Species Reactivity: Tested: Mouse Expected from sequence similarity: Human, rat
Purification Protein G
Alternative Name CD254 / RANKL
Background TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4,5). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3). Mouse Trance/RANKL is a 316 amino acid protein.
Alternate names: ODF, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK Ligand, RANKL, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, TNFSF11, TRANCE, Tumor necrosis factor ligand superfamily member 11
Gene ID 21943
NCBI Accession NP_035743.2
UniProt O35235
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Anderson, Maraskovsky, Billingsley et al.: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, 1997 (PubMed).

Wong, Josien, Lee et al.: "TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor." in: The Journal of experimental medicine, Vol. 186, Issue 12, pp. 2075-80, 1998 (PubMed).

Lacey, Timms, Tan et al.: "Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation." in: Cell, Vol. 93, Issue 2, pp. 165-76, 1998 (PubMed).

Kong, Yoshida, Sarosi et al.: "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis." in: Nature, Vol. 397, Issue 6717, pp. 315-23, 1999 (PubMed).

Hsu, Lacey, Dunstan et al.: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

Hosts (110), (26), (20), (7)
Reactivities (110), (92), (32), (25), (13), (1), (1)
Applications (120), (79), (35), (28), (20), (19), (14), (13), (8), (6), (5), (5), (3), (2), (2), (2), (1)
Conjugates (22), (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (8), (8), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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