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TRAF Interacting Protein (TRAIP) (AA 294-313) antibody

Details for Product No. ABIN569524
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Antigen
Epitope
AA 294-313
(8), (2), (2), (1), (1)
Reactivity
Human
(23), (3), (3)
Host
Rabbit
(11), (6), (6)
Clonality
Polyclonal
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(19), (11), (8), (6), (4), (2), (2)
Pubmed 2 references available
Quantity 50 µL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN569524
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Immunogen Synthetic peptide corresponding to amino acids 294-313 of human TRIP
Sequence ESPAPVEVNLKLRRPSFRDD
Specificity This antibody detects TRAIP / RNF206. Species Reactivity: Tested: Human
Purification Serum
Alternative Name TRAIP / RNF206
Background The TNF receptor-associated factor (TRAF) family is a group of cytoplasmic adapter proteins that link a wide variety of cell surface receptors including the TNF and IL-1 receptor (TRNFR and IL-1R) superfamily to diverse signaling cascades involved in differentiation, proliferation, activation and apoptosis. TRIP (TRAF-interacting protein) was identified in 1997 as a component of receptor-TRAF signaling complexes (Lee, 1997). TRIP (also known as TRAIP) has been shown to associate with TRNFR2 or CD30 signaling complexes through its interaction with TRAF proteins and inhibit TRAF2-mediated NF-kB activation (Lee, 1997, Regamey et al, 2003). The recruitment of different TRAFs and TRAF associated proteins like TRIP to receptor complexes can help regulate and provide specificity to the intracellular signals triggered by the cell surface receptors.
Alternate names: RING finger protein 206, TRAF-interacting protein, TRIP
Gene ID 10293
NCBI Accession NP_005870.2
UniProt Q9BWF2
Restrictions For Research Use only
Format Liquid
Buffer 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Lee, Lee, Choi: "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation." in: The Journal of experimental medicine, Vol. 185, Issue 7, pp. 1275-85, 1997 (PubMed).

Regamey, Hohl, Liu et al.: "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor." in: The Journal of experimental medicine, Vol. 198, Issue 12, pp. 1959-64, 2003 (PubMed).

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